北京市城区中老年人群脂蛋白脂酶基因变异与肥胖代谢综合征的关系  

The Relations of Lipoprotein Lipase Gene Variation with Obesity-related Metabolism Syndrome in Middle-aged and Elderly Population from Beijing Urban Districts

作　　者：朱文丽[1] 齐智[1] 张震涛[1] 肖颖[1] 

机构地区：[1]北京大学医学部营养与食品卫生学系,北京100083

出　　处：《中国慢性病预防与控制》2002年第5期210-212,240,共4页Chinese Journal of Prevention and Control of Chronic Diseases

摘　　要：目的了解脂蛋白脂酶 (L PL)基因 Pvu 位点多态性与肥胖代谢综合征的关系。方法对北京市西城区 2 11例超重 (BMI≥ 2 5 )和 93例体重正常的中老年人 (33～ 78岁 )进行 L PL- Pvu 位点多态性分析、体格检查及血生化指标检测。结果超重组与体重正常组 L PL- Pvu 位点基因型构成差异无显著性意义。L PL- Pvu 位点 (- /- )基因型携带者腰臀比低于 (+/+)基因型 ,HDL- C水平高于 (+/+)型 ,舒张压水平高于 (+/- )基因型 (P<0 .0 5 )。多因素分析显示腰臀比在 (+/+)、(+/- )和 (- /- )三种基因型间递减。结论 L PL基因 Pvu 位点 (- /- )基因型与腰臀比降低及 HDL- C水平升高有关 ,是肥胖代谢综合征的保护因素。Objective To investigate the relations of lipoprotein lipase gene-Pvu Ⅱ locus to obesity-related metabolism syndrome.Methods For all 211 overweight(BMI≥25) and 93 normal weight subjects (aged 33 to 81 years old),the polymorphism at LPL-Pvu Ⅱ locus were analyzed (PCR-RFLP),and physical examination,serum biochemical indexes were detected.Results There were no significant difference for the LPL-Pvu Ⅱ genotype distribution between overweight and control group.The levels of waist-hip ratio in (-/-) genotype carriers were significantly lower and HDL-C was higher than those in(+/+) genotype,and DBP higher than in (-/+)genotype(P<0.05).The multifactor analyses showed that WHR levels were gradually decreased in(+/+),(+/-)and(-/-)genotype.Conclusion The(-/-)genotype at LPL-Pvu Ⅱ locus was associated with decrease of WHR and increase of HDL-C,and it was a protective factor for obesity-related metabolism syndrome.

关 键 词：北京 中老年人 脂蛋白脂酶 基因变异 肥胖代谢综合征 PCR 

分 类 号：R589.2[医药卫生—内分泌]