血钙、 PTHrP、PTH1R 水平在NSCLC骨转移诊断及放疗疗效评价中的价值  

Value of blood calcium,PTHrP and PTH1R for the diagnosis of bone metastasis in NSCLC and the evaluation of radiotherapy efficacy

作　　者：王苏 高志棣[2] 鹿涛 刘鹏[1] 赵克欣 WANG Su;GAO Zhidi;LU Tao;LIU Peng;ZHAO Kexin(Qingdao Hiser Hospital Affiliated of Qingdao University(Qingdao Traditional Chinese Medicine Hospital)Oncology Department,Shandong Qingdao 266000,China;Qingdao Sixth People's Hospital Affiliated of Qingdao University,Shandong Qingdao 266033,China;Qingdao West Coast New Area Central Hospital,Shandong Qingdao 266555,China)

机构地区：[1]青岛大学附属青岛市海慈医院(青岛市中医医院)肿瘤中心,山东青岛266000 [2]青岛大学附属青岛市第六人民医院,山东青岛266033 [3]青岛西海岸新区中心医院,山东青岛266555

出　　处：《现代肿瘤医学》2025年第1期45-50,共6页Journal of Modern Oncology

基　　金：山东省中医药科技发展计划项目(编号:2019-0607);山东省青岛市科技惠民示范引导专项(编号:20-3-4-49-NSH)。

摘　　要：目的:探讨血钙、血清甲状旁腺激素相关蛋白(PTHrP)及甲状旁腺激素受体1(PTH1R)水平与非小细胞肺癌(NSCLC)骨转移的相关性及其在放疗疗效评价中的价值。方法:选取NSCLC骨转移和非骨转移患者各40例,骨转移组接受骨转移灶局部放疗。分析放疗前两组患者血钙、PTHrP、PTH1R水平的差异,骨转移组三者与骨转移数目、病程间的相关性,并观察骨转移组放疗后其水平的变化。结果:NSCLC骨转移组血钙、PTHrP及PTH1R水平均高于非骨转移组(P<0.05)。骨转移数目>3处的患者PTHrP水平高于≤3处的患者(P<0.05)。病程越长,PTHrP水平越高(P<0.01)。放疗后患者血钙、PTHrP水平较治疗前显著降低(P<0.001)。结论:血钙、PTHrP、PTH1R水平有助于诊断NSCLC骨转移,而血钙、血清PTHrP水平或可作为放疗疗效评价的参考指标。Objective:To investigate the correlation of serum calcium,serum parathyroid hormone-related protein(PTHrP)and parathyroid hormone receptor 1(PTH1R)levels with bone metastasis in non-small cell lung cancer(NSCLC),and its value in the evaluation of radiotherapy efficacy.Methods:40 NSCLC patients with bone metastasis receiving local radiotherapy and treatment of zoledronic acid were investigated.40 patients with bone and 40 patients of non-bone metastases from NSCLC were selected.Patients with bone metastases received radiotherapy.Compare the levels of calcium,serum PTHrP,and PTH1R between the two groups before treatment.The correlation between the levels of three different blood substances,and the number of bone metastatic sites,course of disease in were analyzed in the bone metastasis group.The changes of the blood calcium,the serum PTHrP and PTH1R levels before and after therapy were also tested.Results:The levels of blood calcium,serum PTHrP and PTH1R were higher in bone metastasis patients than in non-bone metastasis patients(P<0.05).Patients with more than 3 bone metastatic sites showed higher PTHrP levels compared with those with≤3 bone metastases(P<0.05).A positive correlation was demonstrated between the course of disease and the PTHrP levels,where the longer course of disease was associated with the higher PTHrP levels(P<0.01).The blood calcium and serum PTHrP levels were significantly reduced due to the radiotherapy(P<0.001).Conclusion:Blood calcium,PTHrP,and PTH1R levels can used for the diagnosis of bone metastasis in NSCLC.The levels of blood calcium and serum PTHrP can be used as reference indicators for the evaluation of radiotherapy efficacy.

关 键 词：肺癌 骨转移 放疗 血钙 PTHRP PTH1R 

分 类 号：R734.2[医药卫生—肿瘤]