Enhancing immune defense against COVID-19:Alveolar delivery of mucosal vaccines  

增强对抗COVID-19的免疫防御策略:肺泡递送黏膜疫苗

作　　者：Pei-Huang Wu Dong-Chun Hong Chu Xie Mu-Sheng Zeng Cong Sun 吴培煌;洪冬纯;谢楚;曾木圣;孙聪

机构地区：[1]State Key Laboratory of Oncology in South China,Guangdong Provincial Clinical Research Center for Cancer,Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy,Sun Yat-sen University Cancer Center,Guangzhou 510060,China [2]Department of Nuclear Medicine,State Key Laboratory of Oncology in South China,Sun Yat-Sen University Cancer Center,Guangzhou 510060,China

出　　处：《Science Bulletin》2024年第23期3637-3639,共3页科学通报(英文版)

基　　金：supported by the Postdoctoral Fellowship Program of CPSF(GZB20230886);the Chinese Postdoctoral Science Foundation(2023M743998,2023M744021,2024T171080);the National Key Research and Development Program of China(2022YFC3400900);the National Natural Science Foundation of China(82030046).

摘　　要：Most approved clinical vaccines for COVID-19 are administered intramuscularly[1].COVID-19 vaccines have played a crucial role in saving countless lives throughout the pandemic and continue to effectively mitigate hospitalization risks for vulnerable individuals.However,it is important to note that updated iterations of these vaccines offer limited and short-lived protection against reinfection and transmission[2,3].To address these limitations,an emerging strategy involves the development of vaccines deliverable through the airways to elicit mucosal immunity[4,5].Recently,Ye et al.[6]developed a dry powder nanoparticlebased SARS-CoV-2 vaccine designed for airway administration.This vaccine,which was an optimal size,was delivered directly into the alveoli through inhalation.In animal models,pulmonary vaccine delivery can induce potent systemic and mucosal immune responses,effectively protecting against COVID-19.Notably,a significant reduction in host-to-host viral transmission has also been demonstrated in vaccinated hamster models,indicating the crucial role of the mucosal immune response in treating respiratory virus infections.

关 键 词：vaccines MUCOSAL IMMUNITY 

分 类 号：R57[医药卫生—消化系统]