What is the role of nonalcoholic fatty liver disease in pulmonary carcinoma development?  

作　　者：Qin Pan Qing-Yang Xu Lang-Hua Zhang Ya-Fang He 

机构地区：[1]Shanghai Institute of Pediatric Research,Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition,Xinhua Hospital,Shanghai Jiao Tong University,School of Medicine,Shanghai 200092,China [2]Department of Gastroenterology,Xinhua Hospital,Shanghai Jiao Tong University,School of Medicine,Shanghai 200092,China [3]School of Health Science and Engineering,University of Shanghai for Science and Technology,Shanghai 200093,China [4]Department of Gastroenterology,Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University,Linhai 317000,Zhejiang Province,China [5]School of Medical Technology,Shanghai University of Medicine and Health Sciences,Shanghai 201318,China [6]Department of Pediatric Respiratory,Xinhua Hospital,Shanghai Jiao Tong University,School of Medicine,Shanghai 200092,China

出　　处：《World Journal of Gastroenterology》2025年第5期7-12,共6页世界胃肠病学杂志(英文)

基　　金：Supported by National Science and Technology Major Project of China,No.2023ZD0508700;National Natural Science Foundation of China,No.81470859;and Program of Taizhou Science and Technology Grant,No.24ywb33.

摘　　要：This article summarizes the epidemiological characteristics and clinical manifest-ations of nonalcoholic fatty liver disease(NAFLD).The incidence of NAFLD has been increased dramatically and become the leading cause of chronic liver disease worldwide.In addition to its adverse outcomes of liver fibrosis,cirrhosis,and hepatocellular carcinoma,and related complications,NAFLD has recently been found to be associated with the high-risk extrahepatic carcinomas,such as various types of lung cancer(i.e.,lung adenocarcinoma,squamous cell carcinoma,and small cell lung cancer).The presence of hepatic steatosis also predisposes lung cancer to liver metastasis,but has better response to immune checkpoint inhibi-tors.Whether other factors(i.e.,gender,smoking,etc.)are associated with NAFLD and lung cancer remains controversial.We also comment on the reciprocal rela-tionships between NAFLD and components of metabolic syndrome.Most meta-bolic syndrome components are suggested to facilitate lung cancer development via activating insulin/insulin-like growth factor axis.In addition,suppressed anti-tumor immunity and accelerated tumor progression could be attributed to the cell-specific metabolic reprogramming in condition of high-fat diet and related obesity.These findings may reveal the role of NAFLD in pulmonary carcinoma and help develop new treatment strategies for this disease.

关 键 词：Nonalcoholic fatty liver disease LUNG CANCER ADENOCARCINOMA Metabolic syndrome COMPONENT 

分 类 号：R575.5[医药卫生—消化系统] R735.7[医药卫生—内科学]