Pegaspargase induced multiple organ failure with acute lymphoblastic leukemia:A case report  

作　　者：Su-Xia Bao Xiao-Ling Yuan Lei Yan Jie Xu 

机构地区：[1]Department of Infectious Diseases,Shanghai Ninth People's Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200011,China

出　　处：《World Journal of Clinical Cases》2025年第13期14-19,共6页世界临床病例杂志(英文)

基　　金：Supported by National Natural Science Foundation of China,No.82100625;Zhejiang Provincial natural Science Foundation of China,No.Q20H030013.

摘　　要：BACKGROUND The introduction of pegaspargase has greatly advanced the treatment of acute lymphoblastic leukemia(ALL).In the literature,only one case of pegaspargaseinduced multiple organ failure has been reported,and the patient died due to multiple organ failure.CASE SUMMARY Herein,we present a rare case of a 40-year-old man with ALL who developed multiple organ failure after treatment with pegaspargase.The patient had two rare phenomena reflecting poor prognosis,including the discrepancy between clinical manifestations and liver function and persistently low alpha-fetoprotein(AFP)levels from subacute liver failure.However,the patient was successfully treated using a multidisciplinary team approach.CONCLUSION This is the first case report of successful treatment of pegaspargase-induced multiple organ failure.The findings emphasize the importance of a multidisciplinary team approach in treating pegaspargase-induced multiple organ failure.

关 键 词：PEGASPARGASE Multiple organ failure Acute lymphoblastic leukemia Liver failure Case report 

分 类 号：R733.71[医药卫生—肿瘤]