PEGASPARGASE

作品数：11被引量：7H指数：2
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Pegaspargase induced multiple organ failure with acute lymphoblastic leukemia:A case report
《World Journal of Clinical Cases》2025年第13期14-19,共6页Su-Xia Bao Xiao-Ling Yuan Lei Yan Jie Xu 
Supported by National Natural Science Foundation of China,No.82100625;Zhejiang Provincial natural Science Foundation of China,No.Q20H030013.
BACKGROUND The introduction of pegaspargase has greatly advanced the treatment of acute lymphoblastic leukemia(ALL).In the literature,only one case of pegaspargaseinduced multiple organ failure has been reported,and t...
关键词：PEGASPARGASE Multiple organ failure Acute lymphoblastic leukemia Liver failure Case report 
Comparison of pegaspargase with concurrent radiation vs.P-GEMOX with sequential radiation in early-stage NK/T-cell lymphoma
《Oncology Research》2025年第4期965-974,共10页DEMEI FENG SHENRUI BAI GUANJUN CHEN BIBO FU CAILU SONG HAILIN TANG LIANG WANG HUA WANG 
funded by the National Natural Science Foundation of China grant 81700148 and Natural Science Foundation of Guangdong Province grant 2021A1515010093 and 2023A1515011862;funded by the National Natural Science Foundation of China grant 82170181;funded by the Basic and Applied Basic Research Foundation of Guangdong Province grant 2022B1515120087.
Objectives:The optimal treatment strategy for early-stage natural killer/T-cell lymphoma(NKTCL)remains unclear.This study aimed to evaluate and compare the clinical outcomes and adverse events(AEs)associated with two ...
关键词：Natural killer/T-cell lymphoma(NKTCL) Concurrent radiation therapy PEGASPARGASE Propensity score matching 
Anti-metabolic agent pegaspargase plus PD-1 antibody sintilimab for first-line treatment in advanced natural killer T cell lymphoma被引量：2
《Signal Transduction and Targeted Therapy》2024年第4期1665-1674,共10页Jie Xiong Shu Cheng Xiao Gao Shan-He Yu Yu-Ting Dai Xin-Yun Huang Hui-Juan Zhong Chao-Fu Wang Hong-Mei Yi Hao Zhang Wei-Guo Cao Rong Li Wei Tang Yan Zhao Peng-Peng Xu Li Wang Wei-Li Zhao 
supported,in part,by research funding from the National Natural Science Foundation of China (82130004 and 82270194);National key research and development program (2022YFC2502600);Chang Jiang Scholars Program,Shanghai Rising-Star Program (23QA1406100);Shanghai Municipal Commission of Science and Technology Project (23141903100);Shanghai Municipal Education Commission Gaofeng Clinical Medicine Grant Support (20152206,20152208,and 20161303);Clinical Research Plan of Shanghai Hospital Development Center (SHDC 2020CR1032B);Multicenter Clinical Research Project by Shanghai Jiao Tong University School of Medicine (DLY201601)。
Natural killer T cell lymphoma(NKTCL)is highly aggressive,with advanced stage patients poorly responding to intensive chemotherapy.To explore effective and safe treatment for newly diagnosed advanced stage NKTCL,we co...
关键词：KILLER METABOLISM LYMPHOMA 
Salvage treatment in IDH1 mutated acute lymphoblastic leukemia with venetoclax plus methotrexate and pegaspargase:A case report
《Genes & Diseases》2023年第6期2215-2217,共3页Dan Li Shuqi Zhao Liping Mao Jie Jin Jinghan Wang 
Acute myeloid leukemia(AML)and acute lymphoblastic leukemia(ALL)are distinct subtypes of acute leukemia with respect to clinical and genetic features.Recently,ALLs were reported to share similar genes like IDH1 mutati...
关键词：IDH1 METHOTREXATE CHEMOTHERAPY 
Analysis of prognostic factors of extranodal NK/T-cell lymphoma treated with pegaspargase/L-asparaginase:a multicenter retrospective study
《China Medical Abstracts(Internal Medicine)》2023年第4期233-234,共2页沈子园 
Objective To explore the prognostic factors of extracellular NK/T cell lymphoma(ENKTL)treated with pegaspargase/L-asparaginase.Methods The clinical data of 656 ENKTL patients diagnosed at 11 medical centers in the Hua...
关键词：LYMPHOMA NK/T CLINICAL 
Comparison of the Effects of L-asparaginase and Pegaspargase in the Treatment of Adult Acute Lymphoblastic Leukemia
《Proceedings of Anticancer Research》2023年第5期7-10,共4页Limin Hou Lan Li 
Objective:To compare the effect of L-asparaginase and pegaspargase in the treatment of adult acute lymphoblastic leukemia.Methods:In this study,96 patients who received treatment at the Shaanxi Provincial People’s Ho...
关键词：PEGASPARGASE L-ASPARAGINASE ADULT Acute lymphoblastic leukemia 
Etoposide,dexamethasone,and pegaspargase with sandwiched radiotherapy in early-stage natural killer/T-cell lymphoma:A randomized phase III study被引量：3
《The Innovation》2023年第3期70-78,共9页Huijuan Zhong Shu Cheng Xi Zhang Bing Xu Jiayi Chen Xufeng Jiang Jie Xiong Yu Hu Guohui Cui Juying Wei Wenbin Qian Xiaobing Huang Ming Hou Feng Yan Xin Wang Yongping Song Jianda Hu Yuanhua Liu Xuejun Ma Fei Li Chongyang Wu Junmin Chen Li Yu Ou Bai Jingyan Xu Zunmin Zhu Li Liu Xin Zhou Li Huang Yin Tong Ting Niu Depei Wu Hao Zhang Chaofu Wang Binshen Ouyang Hongmei Yi Qi Song Gang Cai Biao Li Jia Liu Zhifeng Li Rong Xiao Luqun Wang Yujie Jiang Yanyan Liu Xiaoyun Zheng Pengpeng Xu Hengye Huang Li Wang Saijuan Chen Weili Zhao 
supported by the Union for China Lymphoma Investigators,and funded by the Multicenter Clinical Research Project by Shanghai Jiao Tong University School of Medicine(DLY201601);the National Key R&D Program of China(2022YFC 2502600);the National Natural Science Foundation of China(82130004,81830007,82070204,and 81670176);Chang Jiang Scholars Program,Shanghai Municipal Education Commission Gaofeng Clinical Medicine Grant Support(20152206 and 20152208);the Clinical Research Plan of Shanghai Hospital Development Center(SHDC2020CR1032B);the Collaborative Innovation Center of Systems Biomedicine,and the Samuel Waxman Cancer Research Foundation.
Methotrexate,etoposide,dexamethasone,and pegaspargase(MESA)with sandwiched radiotherapy is known to be effective for early-stage extranodal natural killer/T-cell lymphoma,nasal type(NKTCL).We explored the efficacy and...
关键词：RADIOTHERAPY KILLER lymphoma 
Combination of gemcitabine,pegaspargase,etoposide,and dexamethasone(GPED)in treatment of advanced extranodal NK/T-cell lymphoma被引量：1
《Chinese Medical Journal》2023年第6期732-734,共3页Ruiying Fu Yuanzheng Liang Liqiang Wei Xindi Liu Yingshi Piao Liang Wang 
National Natural Science Foundation of China(No.82170181);Beijing Hospitals Authority Youth Programme(No.QML20200201);Beijing Natural Science Foundation(No.7222027);CSH Young Scholars and 3SBioPharmaceutical joint research project(No.KYC2201001)
To the Editor:Extranodal natural killer/T-cell lymphoma(ENKTCL)is a highly aggressive lymphoma,closely associated with Epstein–Barr virus(EBV)infection.By using the combination of radiotherapy(RT)and asparaginase-bas...
关键词：LYMPHOMA chemotherapy EPSTEIN 
Using Pegaspargase in Combination with Chemotherapy in the Treatment of Lymphoma
《Proceedings of Anticancer Research》2022年第4期21-25,共5页Yudi Miao 
Objective:To analyze the clinical effect of pegaspargase combined with chemotherapy on patients with lymphoma.Methods:Seventy patients with lymphoma admitted to Shaanxi Provincial People’s Hospital between December 2...
关键词：Pegaspargase combined with chemotherapy Conventional treatment LYMPHOMA 
Chronic active Epstein-Barr virus infection treated with PEGaspargase: A case report被引量：1
《World Journal of Clinical Cases》2021年第26期7845-7849,共5页De-Li Song Jing-Shi Wang Lei-Lei Chen Zhao Wang 
Supported by National Natural Science Foundation of China,No.81871633;Beijing Natural Science Foundation,No.7181003;Beijing Municipal Administration of Hospitals’Ascent Plan,No.DFL20180101.
BACKGROUND Chronic active Epstein-Barr virus infection(EBV)is a systemic EBV-positive lymphoproliferative disease,which may lead to fatal illness.There is currently no standard treatment regimen for chronic active EBV...
关键词：Chronic active Epstein-Barr virus infection PEG-aspargase CHEMOTHERAPY L-ASPARAGINASE Case report 
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