青少年早发克莱恩-莱文综合征1例  

A case of early-onset Kleine-Levin syndrome in adolescence

作　　者：马月娇 徐健昌 李秀娟 李颖源 李奕 林秋雁 卢建平[1] Ma Yuejiao;Xu Jianchang;Li Xiujuan;Li Yingyuan;Li Yi;Lin Qiuyan;Lu Jianping(Department of Child and Adolescent Psychiatry,Shenzhen Kangning Hospital,Shenzhen Mental Health Center,Shenzhen518020,China)

机构地区：[1]深圳市精神卫生中心,深圳市康宁医院儿少精神科,深圳518020

出　　处：《中华精神科杂志》2025年第1期55-58,共4页Chinese Journal of Psychiatry

摘　　要：克莱恩-莱文综合征(Kleine-Levin syndrome,KLS)是一种罕见的复发-缓解型睡眠障碍,主要表现为周期性嗜睡、贪食和性欲亢进三联征,并伴有认知功能障碍、感知觉障碍、情绪改变或精神行为异常等症状。患者通常经历反复发作,嗜睡期持续几天到几周,多数KLS患者间歇期各项功能均恢复正常,而青少年早发KLS病例较少见,通常频繁发作,且症状复杂多样,易导致误诊。本文中我们分析了1例KLS青少年患者的详细病史、实验室检查、鉴别诊断及诊疗情况,并进行文献复习,为深入了解青少年早发KLS的复杂症状和诊断提供帮助。Kleine-Levin syndrome(KLS)is a rare,recurrent-remitting sleep disorder characterized by periodic hypersomnia,hyperphagia,and hypersexuality,accompanied by cognitive dysfunction,perceptual disturbances,mood changes,or psychiatric abnormalities.Patients typically experience recurrent episodes,with hypersomnic periods lasting from several days to weeks.Most KLS patients exhibit normal functions during the intermission period,while early-onset KLS cases in adolescents are rare,often presenting with frequent episodes and complex symptoms,which can easily lead to misdiagnosis.Therefore,this case report analyzed the detailed medical history,laboratory findings,differential diagnosis,and treatment of a teenage patient with KLS,along with a review of the literature.This case aims to provide a deeper understanding of the complex symptoms and diagnostic challenges associated with early-onset KLS in adolescents.

关 键 词：克莱恩-莱文综合征 青少年 复发缓解型睡眠障碍 

分 类 号：R740[医药卫生—神经病学与精神病学]