Gamma-glutamyl transferase-to-lymphocyte ratio as a prognostic marker in patients with hepatocellular carcinoma undergoing hepatectomy  

作　　者：Peng-Cheng Zhou Rui Huang Hai-Tao Wang Jun Yang Jian-Dong Peng Zi-Xuan Fu Wen-Jun Liao Hai-Qiang Ma Lin-Quan Wu En-Liang Li 

机构地区：[1]Department of General Surgery,The Second Affiliated Hospital,Jiangxi Medical College,Nanchang University,Nanchang 330008,Jiangxi Province,China [2]School of Statistics and Data Science,Jiangxi University of Finance and Economics,Nanchang 330013,Jiangxi Province,China [3]Department of General Surgery and Thoracic Surgery,Jishui County People's Hospital,Ji’an 331600,Jiangxi Province,China

出　　处：《World Journal of Gastrointestinal Surgery》2025年第2期64-76,共13页世界胃肠外科杂志(英文)

基　　金：Supported by the National Natural Science Foundation of China,No.82060447 and No.82260553;the Key Project of Jiangxi Provincial Natural Science Foundation,No.20224ACB206035;the General Project of Jiangxi Provincial Natural Science Foundation,No.20232BAB206109;Jiangxi Provincial Natural Science Foundation,No.20242BAB26002;the Youth Project of Jiangxi Provincial Natural Science Foundation,No.20224BAB216057.

摘　　要：BACKGROUND We investigated the utility of gamma-glutamyl transferase-to-lymphocyte ratio(GLR)as a predictive indicator for postoperative survival in patients with hepatocellular carcinoma(HCC)across different time periods and developed a predictive model based on this.AIM To evaluate the prognostic accuracy of GLR for overall survival(OS)in patients with HCC and its impact over time.METHODS This study enrolled 301 patients with HCC treated with curative hepatectomy.Exclusion criteria included non-HCC hepatic malignancies,inadequate records,and prior cancer treatments.Baseline demographics,clinical features,and hematological parameters were recorded.Time-dependent receiver operating characteristic curve analysis was used to determine the optimal GLR threshold for survival prediction at 13 months.Statistical analyses included the Kaplan-Meier method,multivariate Cox regression,and the creation of a prognostic nomogram.RESULTS Out of 301 patients,293 were eligible for analysis,with a male predominance(84.6%).High preoperative GLR correlated with several adverse clinical features.Optimal cutoff values for GLR were significantly associated with stratification of 13-month OS.Multivariate analysis identified age,liver enzymes,postoperative transarterial chemoembolization,Child-Pugh grade,and inflammatory markers as independent predictors of OS.Notably,GLR had a significant impact on long-term postoperative OS,with its influence becoming more pronounced over time.CONCLUSION GLR can serve as a potent prognostic tool for postoperative HCC management,particularly in predicting long-term outcomes.

关 键 词：Hepatocellular carcinoma BIOMARKER Survival TIME-DEPENDENT NOMOGRAM 

分 类 号：R735.7[医药卫生—肿瘤]