Haematology results,inflammatory haematological ratios,and inflammatory indices in cervical cancer:How is the difference between cancer stage?  

作　　者：Phey Liana Hanif Gusneri Syahbiran Nurmalia Purnama Sari Kemas Yakub Rahadiyanto Raissa Nurwany Wahyudi Nurhidayat Tungki Pratama Umar 

机构地区：[1]Department of Clinical Pathology,Faculty of Medicine,Universitas Sriwijaya-Dr.Mohammad Hoesin General Hospital,Palembang 30114,Sumatera Selatan,Indonesia [2]Department of Medicine Programme,Faculty of Medicine,Universitas Sriwijaya,Palembang 30114,Sumatera Selatan,Indonesia [3]Department of Clinical Pathology,Faculty of Medicine,Universitas Sriwijaya,Palembang 30114,Sumatera Selatan,Indonesia [4]Department of Physiology and Medical Physics,Faculty of Medicine,Universitas Sriwijaya,Palembang 30114,Sumatera Selatan,Indonesia [5]Department of Radiotherapy,Dr.Mohammad Hoesin General Hospital,Palembang 30114,Sumatera Selatan,Indonesia [6]Division of Surgery and Interventional Science,Faculty of Medical Sciences,University College London,London WC1E 6BT,United Kingdom

出　　处：《World Journal of Experimental Medicine》2025年第1期80-87,共8页世界实验医学杂志(英文)

摘　　要：BACKGROUND Cervical cancer is a prevalent form of cancer affecting women worldwide and it is the second most common cancer among women in Indonesia,accounting for 8.5%of all cancer-related deaths.Cervical cancer progression can be evaluated through laboratory tests to detect anaemia,an increased platelet count,and elevated inflammatory markers,therefore,effective laboratory examination is crucial for early detection and treatment of cervical cancer.AIM To evaluate the association between laboratory findings(haematology,haematology index,and inflammatory index)and the clinical stage of cervical cancer.METHODS This cross-sectional study analyzed adult cervical cancer patients’data from medical records and laboratory results including sociodemographic status,histopathological finding,clinical stage,and complete haematology examination.Numerical data was analyzed by the one-way ANOVA(normal data distribution),while the Kruskal-Wallis test was used for non-parametric data(abnormal distribution),followed by appropriate post-hoc analysis.The categorical data was analyzed by the Chi-square or Fisher Exact tests.The significance level was established at a P value<0.05.RESULTS This study involved the data of 208 adult cervical cancer patients and found no association between age,marital history,parity history,hormonal contraceptive use and cervical cancer stages.There were significant differences in the clinical laboratory test results based on the clinical stage of cervical cancer,including haemoglobin levels(P<0.001),leucocytes(P<0.001),neutrophils(P<0.001),monocytes(P=0.002),lymphocytes(P=0.006),platelets(P<0.001),neutrophil-lymphocyte ratio/NLR(P<0.001),lymphocyte-monocyte ratio/LMR(P<0.001),and plateletlymphocyte ratio/PLR(P<0.001).There were also significant differences in the systemic inflammatory index(SII)and systematic inflammatory response index(SIRI)between stage III+IV cervical cancer and stage II(SII P<0.001;SIRI P=0.001)and stage I(SII P<0.001;SIRI P=0.016),associated with the shifts in previously mentione

关 键 词：Cervical cancer HAEMATOLOGY Haematology index INFLAMMATION MALIGNANCY 

分 类 号：R737.3[医药卫生—肿瘤] R446.11[医药卫生—临床医学]