Rosa moschata ameliorates haloperidol-induced Parkinson's disease via reduction of neurodegeneration and oxidative stress  

作　　者：Badriyah S.Alotaibi Uzma Saleem Maryam Farrukh Zunera Chaudhary Nabia Anwar Ifat Alsharif Abdullah R.Alanzi Tasahil S.Albishi Fatima A.Jaber Wedad Saeed Al-Qahtani Muhammad Ajmal Shah 

机构地区：[1]Department of Pharmaceutical Sciences,College of Pharmacy,Princess Nourah bint Abdulrahman University,P.O.Box 84428,Riyadh 11671,Saudi Arabia [2]Punjab University College of Pharmacy,University of the Punjab,Lahore-54000,Pakistan [3]Department of Pharmacology,Faculty of Pharmaceutical Sciences,Govt.College University,Faisalabad-38000,Pakistan [4]Department of Biology,Jamoum University College,Umm Al-Qura University-21955 Makkah,Saudi Arabia [5]Department of Pharmacognosy,College of Pharmacy,King Saud University,Riyadh-11451,Saudi Arabia [6]Department of Biology,College of Sciences,Umm Al-Qura University,Makkah,Saudi Arabia [7]Department of Biological Sciences,College of Science,University of Jeddah,Jeddah 21589,Saudi Arabia [8]Department of Forensic Sciences,College of Criminal Justice,Naif Arab University for Security Sciences,P.O.Box 6830,Riyadh 11452,Saudi Arabia [9]Department of Pharmacy,Hazara University,Mansehra-21300,Pakistan

出　　处：《Asian Pacific Journal of Tropical Biomedicine》2025年第1期24-33,I0013-I0015,共13页亚太热带生物医学杂志(英文版)

基　　金：This work was supported by the Princess Nourah bint Abdulrahman University Researchers Supporting Project number(PNURSP2025R73);Princess Nourah bint Abdulrahman University,Riyadh,Saudi Arabia,and researchers supporting project number(RSPD2025R885)at King Saud University Riyadh Saudi Arabia。

摘　　要：Objective:To investigate the effect of Rosa moschata(R.moschata)extract on haloperidol-induced Parkinson’s disease(PD)in rats.Methods:Haloperidol(1 mg/kg)was given to rats intraperitoneally for 3 weeks for induction of PD.R.moschata extract(150,300 and 600 mg/kg)was administered orally for 21 days.The neuroprotective role of R.moschata leaf extract in PD was explored by performing neurobehavioral tests and RT-PCR analysis and measuring neurotransmitters and oxidative stress biomarkers.Results:An improvement in motor functions and muscle strength was observed in PD rats treated with R.moschata extract.The levels of dopamine,serotonin,noradrenaline,superoxide dismutase,catalase,glutathione,and superoxide dismutase were significantly increased(P<0.001),whereas acetylcholinesterase and malondialdehyde levels were markedly decreased by treatment with R.moschata extract(P<0.001).The extract also markedly downregulated the mRNA expressions of IL-1β,α-synuclein,IL-1α,and TNF-αin brain tissue.Moreover,histopathological analysis indicated that neurofibrillary tangles and plaques were noticeably decreased in a dose-dependent manner in PD rats treated with R.moschata extract.Conclusions:R.moschata extract alleviates haloperidol-induced PD in rats by reducing oxidative stress and neurodegeneration.It may be used for management and treatment of PD.However additional studies are required to confirm its efficacy and molecular mechanisms.

关 键 词：Parkinson’s disease Rosa moschata Neurotransmitter α-Synuclein HALOPERIDOL NEURODEGENERATION 

分 类 号：R742.5[医药卫生—神经病学与精神病学] R285.5[医药卫生—临床医学]