黄酮类化合物抗抑郁作用研究进展  

Research Progress on the Antidepressant Effects of Flavonoids

作　　者：郝丹丹 李涛 彭小雨 李威 郭丹颖 汪家琦 付复华 苏东林 李绮丽 潘丽娜 李高阳 Hao Dandan;Li Tao;Peng Xiaoyu;Li Wei;Guo Danying;Wang Jiaqi;Fu Fuhua;Su Donglin;Li Qili;Pan Lina;Li Gaoyang(Ausnutria Dairy(China)Co.,Ltd.,Changsha 410200;Longping Branch,College of Biology,Hunan University,Changsha 410125;Hunan Agricultural Products Processing Institute,Changsha 410125)

机构地区：[1]澳优乳业(中国)有限公司,长沙410200 [2]湖南大学生物学院隆平分院,长沙410125 [3]湖南省农产品加工研究所,长沙410125

出　　处：《中国食品学报》2024年第12期464-478,共15页Journal of Chinese Institute Of Food Science and Technology

基　　金：湖南省农业科技创新资金项目(2022CX02);长沙市自然科学基金项目(kq2202334);湖南省创新平台与人才计划项目(2019TP2066)。

摘　　要：抑郁症是现代社会最常见的一种心理疾病,严重影响身心健康。当前,治疗抑郁症的药物长期使用可能导致多种不良反应,迫切需要寻找新的途径来改善抑郁症状,减少副作用。黄酮类化合物普遍存在于植物中,对人体健康具有积极影响,已有多项研究证实其具有显著的抗抑郁作用。本文从神经递质、神经营养、炎症反应、氧化应激、下丘脑-垂体-肾上腺轴、微生物-肠道-大脑轴6个方面综述抑郁症的形成机制。针对发病途径阐明黄酮类化合物改善认知和情绪,发挥抗抑郁作用的主要成分及作用机制,为膳食预防、改善抑郁症相关功能食品的开发提供理论依据。Depression is one of the most common psychological disorder in modern society,which seriously affecting both mental and physical health.Currently,long term use of medications for treating depression could result in various adverse reactions.Therefore,there is an urgent need to find new approaches to improve depression symptoms while minimizing side effects.Dietary flavonoids are commonly present in plants and have a positive impact on human health.Several studies have confirmed their significant antidepressant effects.This article provides an overview of the mechanisms underlying depression from six aspects:neurotransmitters theory,neurotrophic theory,neuroinflammatory,oxidative stress,hypothalamic-pituitary-adrenal axis,and the microbiota-gut-brain axis.It elaborates on the formation mechanisms of depression and elucidates how flavonoids can improve cognition and emotions,acting as the main components for alleviating depressive symptoms.This paper serves as a theoretical basis for the development of dietary prevention,as well as the improvement of depression and related functional foods.

关 键 词：黄酮类化合物 抑郁症 机制 

分 类 号：TS201.4[轻工技术与工程—食品科学]