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作 者:Surendra Sarsaiya Liu Bo Archana Jain Pan Hong Shi Jingshan Surendra Sarsaiya;刘波;Archana Jain;潘虹;石京山(遵义医科大学基础药理学重点实验室暨特色民族药教育部国际合作联合实验室,贵州遵义563006;遵义医科大学生物资源健康利用研究所,贵州遵义563006;遵义医科大学药学院,贵州遵义563006)
机构地区:[1]Key Laboratory of Basic Pharmacology and Joint International Research Laboratory of Ethnomedicine of Ministry of Education,Zunyi Medical University,Zunyi Guizhou 563006,China [2]Bioresource Institute for Healthy Utilization,Zunyi Medical University,Zunyi Guizhou 563006,China [3]School of Pharmacy,Zunyi Medical University,Zunyi Guizhou 563006,China
出 处:《遵义医科大学学报》2025年第1期77-97,共21页Journal of Zunyi Medical University
基 金:国家自然科学基金资助项目(NO:U1812403)。
摘 要:Objective Alzheimer’s disease(AD)presents a significant global health challenge with a steadily increasing prevalence and impact.This comprehensive review aimed to delve into the epidemiology,pathophysiology,pharmacological therapies,emerging research,challenges,and future directions of AD.Major findings from recent studies were synthesised,encompassing insights into the global prevalence,molecular pathology,high-risk factors,and therapeutic interventions,including cholinesterase inhibitors,glutamate receptor antagonists,and antibodies against Aβand tau proteins.Additionally,emerging research areas such as gene therapy and lipid nanoparticles were highlighted.This review emphasised the urgent need for ongoing research on novel therapeutic avenues and addressing the challenges in AD diagnosis,treatment,and care.Future perspectives underscore the potential of disease-modifying treatments,personalised medical approaches,and holistic interventions to alleviate the growing burden of AD on individuals,families,and healthcare systems worldwide.By fostering collaboration and innovation,we can strive towards a future where effective prevention,early detection,and personalised treatments enhance the lives of millions affected by AD globally.目的阿尔茨海默病(AD)的患病率和死亡率与日俱增,成为了全球健康面临的重大挑战。本文就AD的流行病学、病理生理学、药物治疗、新兴研究、挑战和未来发展方向进行了综述。围绕AD的全球患病率、分子病理学、高危因素、治疗干预措施如胆碱酯酶抑制剂、谷氨酸受体拮抗剂、Aβ和tau蛋白抗体和基因治疗、脂质纳米颗粒等新兴领域的最新研究进行总结。此外,强调迫切需要针对AD新的治疗途径以解决诊断、治疗和护理面临的挑战。同时展望了疾病修饰治疗、精确医疗和整体干预措施在减轻AD患者家庭和医疗保健系统负担的潜力。通过合作和创新,实现AD的有效预防、早期发现和精准治疗,可以给全球数百万AD患者带来福音。
关 键 词:alzheimer’s disease EPIDEMIOLOGY PATHOPHYSIOLOGY pharmacological therapies treatment prevention
分 类 号:R749.1[医药卫生—神经病学与精神病学]
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