Gut Microbiome and Stroke:a Bidirectional Mendelian Randomisation Study in East Asian and European Populations  

作　　者：Shiyao Cheng Hao Zheng Yuandan Wei Xingchen Lin Yuqin Gu Xinxin Guo Zhe Fan Hao Li Si Cheng Siyang Liu 

机构地区：[1]School of Public Health(Shenzhen),Sun Yat-sen University,Shenzhen 518107,Guangdong,China [2]China National Clinical Research Center for Neurological Diseases,Beijing 100070,China [3]Changping Laboratory,Beijing 100000,China [4]Center of excellence for Omics Research(CORe),Beijing Tiantan Hospital,Capital Medical University,Beijing 100070,China [5]Department of Neurology,Beijing Tiantan Hospital,Capital Medical University,Beijing 100070,China [6]Clinical Center for Precision Medicine in Stroke,Capital Medical University,Beijing 100069,China

出　　处：《Stroke & Vascular Neurology》2024年第6期623-630,共8页卒中与血管神经病学(英文)

基　　金：National Key R&D Program of China(2022YFC2502400,2022YFC2502402,2022YFE0209600);National Natural Science Foundation of China(82101359,82111530203,U20A20358,31900487);Capital's Funds for Health Improvement and Research(2020-1-2041);Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(2019-I2M-5-029).

摘　　要：Background and aims Observational studies have implicated the involvement of gut microbiome in stroke development.Conversely,stroke may disrupt the gut microbiome balance,potentially causing systemic infections exacerbated brain infarction.However,the causal relationship remains controversial or unknown.To investigate bidirectional causality and potential ethnic differences,we conducted a bidirectional two-sample Mendelian randomisation(MR)study in both East Asian(EAS)and European(EU)populations.Methods Leveraging the hitherto largest genome-wide association study(GWAS)summary data from the MiBioGen Consortium(n=18340,EU)and BGI(n=2524,EAS)for the gut microbiome,stroke GWAS data from the GIGASTROKE Consortium(264655 EAS and 1308460 EU),we conducted bidirectional MR and sensitivity analyses separately for the EAS and EU population.Results We identified nominally significant associations between 85 gut microbiomes taxa in EAS and 64 gut microbiomes taxa in EU with stroke or its subtypes.Following multiple testing,we observed that genetically determined 1 SD increase in the relative abundance of species Bacteroides pectinophilus decreased the risk of cardioembolic stroke onset by 28%(OR 0.72(95%CI 0.62 to 0.84);p=4.22e-5),and that genetically determined 1 SD increase in class Negativicutes resulted in a 0.76%risk increase in small vessel stroke in EAS.No significant causal association was identified in the EU population and the reverse MR analysis.Conclusion Our study revealed subtype-specific and population-specific causal associations between gut microbiome and stroke risk among EAS and EU populations.The identified causality holds promise for developing a new stroke prevention strategy,warrants further mechanistic validation and necessitates clinical trial studies.

关 键 词：prevention INVOLVEMENT holds 

分 类 号：R743.3[医药卫生—神经病学与精神病学]