Inflammasomes and their roles in autoimmune diseases  

作　　者：Minghui Pan Jie Yang Zhengfan Jiang 

机构地区：[1]Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education,School of Life Sciences,Peking University,Beijing,China

出　　处：《Rheumatology & Autoimmunity》2024年第4期197-217,共21页风湿病与自身免疫(英文)

基　　金：supported by the Ministry of Science and Technology of the People's Republic of China,Grant/Award Number:2023YFC2306102;National Natural Science Foundation of China,Grant/Award Number:32130038.

摘　　要：Autoimmune diseases are immune disorders in which the immune system mistakenly targets and attacks the normal cells,tissues,and organs of the patients.The etiology of autoimmune diseases is complex and multifactorial.This review aims to provide a general introduction to the immunological functions of inflammasomes and describe the role of inflammasomes in disorders characterized by self-directed inflammation,with a particular focus on several common autoimmune diseases.We reviewed current research on the mechanisms of inflammasome activation and inflammasomes'contribution to autoimmune diseases.Inhibitors targeting inflammasome components were also explored for their potential in therapeutic applications.With increasing research on mechanisms of inflammation of the pathologic conditions,accumulated evidence suggests that the aberrant or uncontrolled activation of inflammasomes contributes to the pathogenesis and development of autoimmune diseases.Additionally,inflammasome-targeting drugs have shown promise in treating autoimmune diseases.Insights into the mechanisms governing inflammasome activation and their roles in autoimmune diseases could contribute to the development of novel anti-inflammatory drugs for the prevention and treatment of autoimmune diseases with enhanced targeting precision and reduced adverse reactions.

关 键 词：autoimmune diseases INFLAMMASOMES INFLAMMATION pro-inflammatory cytokines 

分 类 号：R59[医药卫生—内科学]