Selective and Scalable Deuteration of Heteroarenes Using Nickel-Based Nanoparticles  

作　　者：Feiyu Qiu Lingyun Yang Yuan Gao Jiapei Yang Aiwen Lei Wu Li 

机构地区：[1]College of Chemistry and Molecular Sciences and the Institute for Advanced Studies(IAS),Wuhan University,Wuhan,Hubei 430072,China [2]College of Chemistry and Chemical Engineering,Jiangxi Normal University,Nanchang,Jiangxi 330022,Chin

出　　处：《Chinese Journal of Chemistry》2024年第23期2993-2998,共6页中国化学(英文版)

基　　金：support from the National Key R&D Program of China(No.2021YFA1500100,A.L.);National Natural Science Foundation of China(22031008,A.L.;212200007,W.L.);Science Foundation of Wuhan(2020010601012192,A.L.).

摘　　要：Deuterium labelling possesses wide applications in pharmaceuticals,chemical science and materials science.Development of efficient methodologies for the synthesis of deuterium labelled compounds,especially hydrogen isotope exchange(HIE),continued to receive an impressive attention over the years.Herein,we developed a nitrogen doped nano-scale nickel catalyst for deuterium incorporation of a variety of nitrogen heterocycles using D_(2)O as the isotope source.The usefulness of this approach has been demonstrated by 10 g-scale for complex pharmaceuticals.This methodology represents a practical and scalable deuteration and the air-and water-stable nanocatalyst enables efficient labelling in a straightforward manner.

关 键 词：DEUTERATION HETEROARENES NICKEL NANOPARTICLES PYRIDINE 

分 类 号：O62[理学—有机化学]