Advancements in understanding chickencoccidiosis:from Eimeria biology to innovativecontrol strategies  

作　　者：Yang Gao Pei Sun Dandan Hu Xinming Tang Sixin Zhang Fangyun Shi Xinlei Yan Wenchao Yan Tuanyuan Shi Si Wang Jun Zou Guangwen Yin Xianyong Liu Hui Dong Xun Suo 

机构地区：[1]National Key Laboratory of Veterinary Public Health and Safety,Key Laboratory of Animal Epidemiology and Zoonosis of Ministry of Agriculture,National Animal Protozoa Laboratory,College of Veterinary Medicine,China Agricultural University,Beijing 100193,China [2]Guangdong Key Laboratory of Animal Conservation and Resource Utilization,Institute of Zoology,Guangdong Academy of Science,Guangzhou 510260,China [3]College of Animal Science and Technology,Guangxi University,Nanning 530004,China [4]Key Laboratory of Animal Biosafety Risk Prevention and Control(North)of MARA,Institute of Animal Sciences,Chinese Academy of Agricultural Sciences,Beijing 100193,China [5]College of Veterinary Medicine,Southwest University,Chongqing 402460,China [6]Shanghai Institute of Precision Medicine,Ninth People’s Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200125,China [7]Food Science and Engineering College,Inner Mongolia Agricultural University,Hohhot 010018,China [8]Parasitology Laboratory,College of Animal Science and Technology,Henan University of Science and Technology,Luoyang 471023,China [9]Institute of Animal Husbandry and Veterinary Medicine,Zhejiang Academy of Agricultural Sciences,Hangzhou 310021,China [10]Department of Neurological Surgery,Feinberg School of Medicine,Northwestern University,Chicago,IL 60611,USA [11]Center for Inflammation,Immunity and Infection,Institute for Biomedical Sciences,Georgia State University,Atlanta,GA,USA [12]College of Animal Science(College of Bee Science),Fujian Agriculture and Forestry University,Fuzhou 350002,China [13]Key Laboratory of Animal Parasitology of Ministry of Agriculture and Rural Affairs,Shanghai Veterinary Research Institute,Chinese Academy of Agricultural Sciences,Shanghai 200241,China

出　　处：《One Health Advances》2024年第1期298-316,共19页全健康进展(英文)

基　　金：supported by the National Natural Science Foundation of China(32302900 and 32373031).

摘　　要：Coccidiosis,an intestinal disease caused by Eimeria protozoan parasites,affects various animal species,and espe-cially poses a significant threat to the poultry industry.The current primary control methods include anticoccidial drugs and vaccines.However,emerging challenges such as drug resistance and vaccine efficacy issues are rooted in the complex life cycle and species diversification of Eimeria.In this review,we first consolidate recent breakthroughs in understanding Eimeria biology,focusing on the parasite development and its intricate interactions with the host,notably its relationships with host immune cells and the gut microbiota.Furthermore,we provide an extensive sum-mary of current control strategies for Eimeria infections.This includes an in-depth analysis of anticoccidial drugs,their mechanisms of resistance,and the increasing utilization of diverse anticoccidial vaccines to combat these challenges.Finally,we highlight the latest innovative strategies leading the way in coccidiosis control.Through an exploration of cutting-edge techniques,we also provide insights into future directions for effectively combating this disease.In conclusion,the future of coccidiosis control lies in the use of a multifaceted approach,integrating advanced bio-logical insights with innovative therapeutic strategies.This review not only serves to enhance our understanding of Eimeria biology but also provides a valuable resource for researchers involved in developing and implementing strategies to manage and control coccidiosis,ensuring the health and productivity of poultry worldwide.

关 键 词：EIMERIA Parasite development DRUGS Vaccines Innovative strategies 

分 类 号：R57[医药卫生—消化系统]