Future of low back pain:unravelling IVD components and MSCs’potential  

作　　者：Raquel Leao Monteiro 

机构地区：[1]P.Porto:Instituto Politecnico Do Porto,ESS,Porto,Portugal

出　　处：《Cell Regeneration》2024年第1期383-393,共11页细胞再生(英文)

摘　　要：This review article focuses on low back pain(LBP)caused by intervertebral disc(IVD)degeneration and the need to better understand the mechanisms involved.The specific roles of cellular populations and molecular pathways in the inflammatory process associated with IVD herniation are not well understood,and suitable models to mimic human IVD complexity are insufficient.However,due to their unique immunomodulatory and pluripotency abili-ties,mesenchymal stem cells(MSCs)have gained recognition in cellular therapy for bone and cartilage regenera-tion.MSCs have shown the potential in facilitating tissue repair and mitigating inflammation-related degenerative events.Therefore,this review article explores the intertwine between the mechanisms of action of IVD components and therapeutic potential of MSCs,exploring their characteristics,how to optimize their use and establish them safely in distinct settings for LPB treatment.

关 键 词：Low back pain Intervertebral disc DEGENERATION Annulus fibrosus Nucleus pulposus MSCS Regenerative medicine 

分 类 号：R32[医药卫生—人体解剖和组织胚胎学]