Cisplatin-coordinated copolythiophene for synergistic chemotherapy and sonodynamic therapy of tumor  

作　　者：Yuanyu Tang EPang Pan Zhu Qiuxia Tan Shaojing Zhao Benhua Wang Chaoyi Yao Xiangzhi Song Minhuan Lan 

机构地区：[1]Hunan Provincial Key Laboratory of Micro&Nano Materials Interface Science,College of Chemistry and Chemical Engineering,Central South University,Changsha,Hunan,China

出　　处：《Smart Molecules》2024年第3期85-93,共9页智能分子(英文)

基　　金：supported by the National Key Research and Development Program of China(No.2022YFA1207600);the National Natural Science Foundation of China(No.62375289,62175262);the Science and Technology Innovation Program of Hunan Province(No.2022RC1201).

摘　　要：Sonodynamic therapy(SDT)is a novel cancer treatment type showing the advantages of high tissue penetration ability,non-invasion,low systemic toxicity,and high selectivity.However,SDT depends on ultrasound(US)irradiation;once US is turned off,the sonosensitizer will stop producing reactive oxygen species(ROS).Moreover,most sonosensitizers generate oxygen-dependent ROS,that is,singlet oxygen(^(1)O_(2)),significantly limiting the therapeutic effect of SDT in treating deep and hypoxic tumor.Therefore,combining SDT with other treatment modalities is essential.Here,we designed and synthesized a series of cisplatin-coordinated copolythiophenes(CPT-Pts),simultaneously generating^(1)O_(2),superoxide anion,and hydroxyl radicals for synergistic chemotherapy and SDT of tumor.The sonodynamic toxicity and cytotoxicity of CPT-Pts were accurately regulated by tuning the monomer ratio of the polythiophene.This copolymerization strategy avoids the side effects originating from the high-dose chemotherapy drug while making up for limiting SDT relying on ultrasonic activation,effectively inhibiting cancer cells and tumors.

关 键 词：CHEMOTHERAPY CISPLATIN POLYTHIOPHENE sonodynamic therapy 

分 类 号：R73[医药卫生—肿瘤]