Emerging roles of small extracellular vesicles in metabolic reprogramming and drug resistance in cancers  

作　　者：Jingcun Shi Ying Shen Jianjun Zhang 

机构地区：[1]Department of Oral and Maxillofacial-Head and Neck Oncology,Shanghai Ninth People’s Hospital,Shanghai Jiao Tong University School of Medicine,College of Stomatology,Shanghai Jiao Tong University,National Center for Stomatology,National Clinical Research Center for Oral Diseases,Shanghai Key Laboratory of Stomatology,Shanghai Research Institute of Stomatology,Shanghai Center of Head and Neck Oncology Clinical and Translational Science,Shanghai 200011,China [2]Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education,Department of Pharmacology and Chemical Biology,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China [3]Collaborative Innovation Center for Clinical and Translational Science by Chinese Ministry of Education&Shanghai,Shanghai 200025,China.

出　　处：《Cancer Drug Resistance》2024年第1期332-356,共25页癌症耐药(英文)

基　　金：supported by grants from the Project of the National Natural Science Foundation of China(grant No.82372871 and 82173148 to Zhang J).

摘　　要：Studies of carcinogenic metabolism have shown that cancer cells have significant metabolic adaptability and that their metabolic dynamics undergo extensive reprogramming,which is a fundamental feature of cancer.The Warburg effect describes the preference of cancer cells for glycolysis over oxidative phosphorylation(OXPHOS),even under aerobic conditions.However,metabolic reprogramming in cancer cells involves not only glycolysis but also changes in lipid and amino acid metabolism.The mechanisms of these metabolic shifts are critical for the discovery of novel cancer therapeutic targets.Despite advances in the field of oncology,chemotherapy resistance,including multidrug resistance,remains a challenge.Research has revealed a correlation between metabolic reprogramming and anticancer drug resistance,but the underlying complex mechanisms are not fully understood.In addition,small extracellular vesicles(sEVs)may play a role in expanding metabolic reprogramming and promoting the development of drug resistance by mediating intercellular communication.The aim of this review is to assess the metabolic reprogramming processes that intersect with resistance to anticancer therapy,with particular attention given to the changes in glycolysis,lipid metabolism,and amino acid metabolism that accompany this phenomenon.In addition,the role of sEVs in disseminating metabolic reprogramming and promoting the development of drug-resistant phenotypes will be critically evaluated.

关 键 词：Small extracellular vesicles metabolic reprogramming drug resistance neoplasms GLYCOLYSIS lipid metabolism amino acid metabolism 

分 类 号：R73[医药卫生—肿瘤]