Targeting NETosis:nature’s alarm system in cancer progression  

作　　者：Yixia Liang Guo Wu Jiabao Tan Xiaoyun Xiao Linbin Yang Phei Er Saw 

机构地区：[1]Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation,Guangdong-Hong Kong Joint Laboratory for RNA Medicine,Medical Research Center,Sun Yat-Sen Memorial Hospital,Sun Yat-Sen University,Guangzhou 510120,Guangdong,China [2]Nanhai Translational Innovation Center of Precision Immunology,Sun Yat-Sen Memorial Hospital,Foshan 528200,Guangdong,China [3]Department of Ultrasound,Sun Yat-sen Memorial Hospital,Sun Yat-sen University,Guangzhou 510120,Guangdong,China [4]Breast Tumor Center,Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation,Medical Research Center,Sun Yat-sen Memorial Hospital,Sun Yat-sen University,Guangzhou 510120,Guangdong,China

出　　处：《Cancer Drug Resistance》2024年第1期531-552,共22页癌症耐药(英文)

基　　金：supported by the National Natural Science Foundation of China(Nos.82072930,82222055,32270971,82001822);Guangzhou Science and Technology Bureau(No.202201020576);111 project(No.B20056);the Guangdong Province Outstanding Youth Award(No.2021B1515020066).

摘　　要：Neutrophils are recognized active participants in inflammatory responses and are intricately linked to cancer progression.In response to inflammatory stimuli,neutrophils become activated,releasing neutrophils extracellular traps(NETs)for the capture and eradication of pathogens,a phenomenon termed NETosis.With a deeper understanding of NETs,there is growing evidence supporting their role in cancer progression and their involvement in conferring resistance to various cancer therapies,especially concerning tumor reactions to chemotherapy,radiation therapy(RT),and immunotherapy.This review summarizes the roles of NETs in the tumor microenvironment(TME)and their mechanisms of neutrophil involvement in the host defense.Additionally,it elucidates the mechanisms through which NETs promote tumor progression and their role in cancer treatment resistance,highlighting their potential as promising therapeutic targets in cancer treatment and their clinical applicability.

关 键 词：NEUTROPHILS neutrophils extracellular traps(NETs) NETosis cancer progression cancer therapeutics 

分 类 号：R73[医药卫生—肿瘤]