CRL3 E3 ligase regulates glutamine and cystine metabolisms  

作　　者：Qiyin Zhou Zhijian Li Yi Sun 

机构地区：[1]Cancer Institute(Key Laboratory of Cancer Prevention and Intervention,China National Ministry of Education),The Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310009,China [2]Institute of Translational Medicine,Zhejiang University School of Medicine,Hangzhou 310029,China [3]Cancer Center,Zhejiang University,Hangzhou 310058,China [4]Zhejiang Provincial Clinical Research Center for Cancer,Hangzhou 310009,China [5]Research Center for Life Science and Human Health,Binjiang Institute of Zhejiang University,Hangzhou 310053,China

出　　处：《Protein & Cell》2024年第12期867-871,共5页蛋白质与细胞(英文版)

基　　金：supported by the National Key Research&Development Program of China(2021YFA1101000 and 2022YFC3401500);National Natural Science Foundation of China(82372688,92253203 and U22A20317);Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang(2022R01002);Zhejiang Provincial Natural Science Foundation of China(LD22H300003)。

摘　　要：Tumorigenesis hinges on the reprogramming of cellular metabolisms to meet the requirements of intracellular biomass,characterized by the acquisition of nutrients from the environment as a common feature(Pavlova and Thompson,2016).Moreover,to fine-tune and support the cellular activities essential for growth and survival,tumor cells integrate multiple metabolic pathways to regulate nutrient availability upon metabolic reprogramming in tumor microenvironment(Lobel et al.,2023).Glutamine is one of the principal nutrients and the most abundant plasma amino acids,and cancer cells are highly dependent on it for proliferation(Yang et al.,2017).Cancer cells uptake glutamine through its transporters and use it as both nitrogen and carbon sources for biosynthetic processes and anabolic metabolites.During the glutaminolysis,glutamine intermediate glutamate can be metabolically converted intoα-ketoglutarate(α-KG)and then it enters into the tricarboxylic acid(TCA)cycle,or be utilized to produce glutathione(Lobel et al.,2023).

关 键 词：METABOLISM PROGRAMMING utilized 

分 类 号：R730.2[医药卫生—肿瘤]