系统生物学在前列腺癌中的应用进展  

Progress in the application of systems biology in prostate cancer

作　　者：周琳 朱晓雨[1] Zhou Lin;Zhu Xiaoyu(Nanjing Hospital of TCM Affiliated to Nanjing University of Traditional Chinese Medicine,Nanjing 210000,Jiangsu,China)

机构地区：[1]南京中医药大学附属南京中医院,江苏南京210000

出　　处：《中国男科学杂志》2024年第6期103-109,共7页Chinese Journal of Andrology

基　　金：南京市中医药青年人才培养计划(宁卫中医〔2020〕4号,ZYQ20005);江苏省研究生科研与实践创新计划项目(苏学位字函〔2023〕4号,SJCX23_0814)。

摘　　要：前列腺癌是男性常见的高发恶性肿瘤,异质性是其主要的病理特征,涉及多因素、多阶段的复杂过程。目前系统生物学已经广泛应用到前列腺癌的研究中,无论是新的肿瘤标志物或是新的治疗靶点都是时下热门,其在发病机制、早期诊断、鉴别诊断、分期及预后评估方面均有极大的发展潜力,有助于前列腺癌的精准化个体诊疗。本文从系统生物学的各组学进行归纳总结,以期为前列腺癌的深入研究提供指导作用。Prostate cancer is a common malignant tumor with high incidence in men,and its main pathological feature is heterogeneity,involving a complex process of multi-factors and multi-stages.At present,systems biology has been widely used in the study of prostate cance,rincluding current popular topic such as new tumor markers and new therapeutic targets,moreover systems biology has also great development potential in pathogenesis explore,early diagnosis,differential diagnosis,staging and prognosis assessment,which is benefit to the precise individual diagnosis and treatment of prostate cancer.In this article,we summarize and discuss omics studies of system biology on prostate cancer for providing guidance for future research of it.

关 键 词：系统生物学 前列腺肿瘤 个体化诊疗 

分 类 号：R737.25[医药卫生—肿瘤] R730.5[医药卫生—临床医学]