先天口面裂的分级分类诊疗专家共识  

Expert consensus on classification and diagnosis of congenital orofacial cleft

作　　者：李承浩[1] 安阳[2] 段小红 郭应坤[4] 刘珊玲[5] 罗红 马端[7] 任芸芸 王旭东[9] 吴晓珊[10] 谢红宁[11] 朱洪平[12] 朱军[13] 石冰[1] Li Chenghao;An Yang;Duan Xiaohong;Guo Yingkun;Liu Shanling;Luo Hong;Ma Duan;Ren Yunyun;Wang Xudong;Wu Xiaoshan;Xie Hongning;Zhu Hongping;Zhu Jun;Shi Bing(State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Dept.of Cleft Lip and Palate Surgery,West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China;Dept.of Plastic Surgery,Peking University Third Hospital,Beijing 100191,China;Clinic of Oral Rare Diseases and Genetic Diseases,School of Stomatology,Air Force Medical University,Xi’an 710032,China;Dept.of Radiology,West China Second University Hospital,Sichuan University,Chengdu 610041,China;Dept.of Medical Genetics/Dept.of Birth Defects and Related Diseases of Women and Children,West China Second University Hospital,Sichuan University,Chengdu 610041,China;Dept.of Ultrasonography/Dept.of Birth Defects and Related Diseases of Women and Children,West China Second University Hospital,Sichuan University,Chengdu 610041,China;Lab of Birth Defects Research,Fudan University,Shanghai 200438,China;Dept.of Ultrasonics,Obstetrics and Gynecology Hospital of Fudan University,Shanghai 200090,China;Dept.of Oral and Craniomaxillofacial Surgery,Shanghai Ninth People’s Hospital,Shanghai JiaoTong University School of Medicine,Shanghai 200011,China;Dept.of Oral and Maxillofacial Surgery,Xiangya Hospital of Central South University,Changsha 410008,China;Dept.of Medical Ultrasonics,The First Affiliated Hospital,Sun Yat-Sen University,Guangzhou 510080,China;Dept.of Oral and Maxillofacial Surgery,Peking University School and Hospital of Stomatology,Beijing 100081,China;National Center for Birth Defect Monitoring,West China Second University Hospital,Sichuan University,Chengdu 610041,China)

机构地区：[1]口腔疾病防治全国重点实验室,国家口腔医学中心,国家口腔疾病临床医学研究中心,四川大学华西口腔医院唇腭裂外科,成都610041 [2]北京大学附属第三医院整形外科,北京100191 [3]空军军医大学口腔医院口腔罕见病与遗传门诊,西安710032 [4]四川大学华西第二医院放射科,成都610041 [5]四川大学华西第二医院医学遗传科/产前诊断中心,成都610041 [6]四川大学华西第二医院超声科/产前诊断中心,成都610041 [7]复旦大学出生缺陷研究中心,上海200438 [8]复旦大学附属妇产科医院超声科,上海200090 [9]上海交通大学医学院附属第九人民医院口腔颅颌面科,上海200011 [10]中南大学湘雅医院口腔颌面外科,长沙410008 [11]中山大学附属第一医院超声医学科,广州510080 [12]北京大学口腔医院口腔颌面外科,北京100081 [13]四川大学华西第二医院国家出生缺陷中心,成都610041

出　　处：《华西口腔医学杂志》2025年第1期1-14,共14页West China Journal of Stomatology

基　　金：四川省科学技术厅中央引导地方科技发展项目(2023-ZYD0111);四川省科学技术厅重点研发项目(2023YFS0245)。

摘　　要：先天口面裂是颌面部最常见的出生缺陷,其预后根据畸形的病因和严重程度的不同有着很大的差别。其中非综合征型先天口面裂的畸形程度较轻且治愈效果好,综合征型先天口面裂常因伴有身体其他器官的异常而致使治疗难度较大,预后较差。本共识对不同严重程度的先天口面裂进行详细的分级分类,并提出相应的诊疗指南,为患者家庭应对产前筛查结果、选择治疗方案提供参考,对我国预防和控制严重出生缺陷发生、促进人口长期均衡发展具有重要意义。Congenital orofacial cleft,the most common birth defect in the maxillofacial region,exhibits a wide range of prognosis depending on the severity of deformity and underlying etiology.Non-syndromic congenital orofacial clefts typically present with milder deformities and more favorable treatment outcomes,whereas syndromic congenital orofacial clefts often manifest with concomitant organ abnormalities,which pose greater challenges for treatment and result in poorer prognosis.This consensus provides an elaborate classification system for varying degrees of orofacial clefts along with corresponding diagnostic and therapeutic guidelines.Results serve as a crucial resource for families to navigate prenatal screening results or make informed decisions regarding treatment options while also contributing significantly to preventing serious birth defects within the development of population.

关 键 词：先天口面裂 分级分类 诊疗 

分 类 号：R782.2[医药卫生—口腔医学]