九味镇心颗粒联合盐酸曲唑酮片治疗青少年焦虑性抑郁症疗效观察  

Efficacy of Jiuwei Zhenxin Granules combined with trazodone hydrochloride tablets in the treatment of adolescent anxious depression

作　　者：和曼玉 史利静 冀紫阳 崔桂梅[1] 王欣宇 邱晨 李嫣然 张金玉 王长虹[1,2] HE Manyu;SHI Lijing;JI Ziyang;CUI Guimei;WANG Xinyu;QIU Chen;LI Yanran;ZHANG Jinyu;WANG Changhong(The Second Affiliated Hospital of Xinxiang Medical University,Xinxiang 453002,Henan Province,China;Henan Collaborative Innovation Center of Prevention and Treatment of Mental Disorder,the Second Affiliated Hospital of Xinxiang Medical University,Xinxiang 453002,Henan Province,China)

机构地区：[1]新乡医学院第二附属医院精神科,河南新乡453002 [2]新乡医学院第二附属医院精神心理疾病防治河南省协同创新中心,河南新乡453002

出　　处：《新乡医学院学报》2025年第2期138-142,共5页Journal of Xinxiang Medical University

基　　金：河南省医学科技攻关计划联合共建项目(编号:LHGJ20220638);河南省重点研发专项(编号:221111311000);中原英才计划(育才系列)。

摘　　要：目的探讨九味镇心颗粒联合盐酸曲唑酮片治疗青少年焦虑性抑郁症的临床疗效及安全性。方法选择2021年10月至2022年12月新乡医学院第二附属医院门诊或者住院治疗的66例青少年焦虑性抑郁症患者为研究对象,根据治疗方法将患者分为对照组和观察组,每组33例。2组患者均给予盐酸曲唑酮片治疗。在此基础上,对照组患者给予九味镇心颗粒模拟剂,每次6 g,每日2次;观察组患者给予九味镇心颗粒,每次6 g,每日2次;2组患者均连续治疗6周。分别于治疗前、治疗第4、6周末,采用汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)评估2组患者的抑郁程度和焦虑程度。在治疗过程中对患者进行开放式主动询问和检查来评估药物不良反应。结果随访期间观察组患者中2例、对照组患者中4例由于自身(学业繁忙)或者家庭原因未能顺利完成治疗过程,为脱落病例,不计入统计量,最终对照组29例,观察组31例患者完成本研究,纳入疗效分析。治疗前,2组患者的HAMD、HAMA评分比较差异无统计学意义(P>0.05)。治疗第4、6周末,2组患者的HAMD、HAMA评分显著低于治疗前(P<0.05);治疗第6周末,2组患者的HAMD、HAMA评分均显著低于治疗第4周末(P<0.05)。治疗第4、6周末,观察组患者HAMD、HAMA评分显著低于对照组(P<0.05)。观察组患者总有效率为96.77%(30/31),对照组患者总有效率为79.31%(23/29);观察组患者总有效率显著高于对照组(χ^(2)=4.434,P<0.05)。观察组患者中6例出现不良反应事件,包括口干1例、便秘1例、干呕1例、头晕2例及嗜睡1例,不良反应发生率为19.4%。对照组患者中7例出现不良反应事件,包括口干1例、便秘2例、干呕2例、头晕1例及嗜睡1例,不良反应发生率为24.1%;2组患者不良反应事件发生率比较差异无统计学意义(χ^(2)=0.202,P>0.05)。结论相较于单独应用盐酸曲唑酮片,联合九味镇心颗粒治疗有助于缓解患者Objective To explore the clinical efficacy and safety of Jiuwei Zhenxin Granules(JZG)combined with trazodone hydrochloride tablets in the treatment of adolescent anxious depression.Methods A total of 66 adolescents with anxious depression treated as outpatients or inpatients in the Second Affiliated Hospital of Xinxiang Medical University from October 2021 to December 2022 were selected as the study objects.These patients were divided into the control group and the observation group according to the treatment methods,with 33 patients in each group.Patients in the two groups received treatment using trazodone hydrochloride tablets.On that basis,the patients in the control group received JZG simulants(6 g each time,twice a day),and those in the observation group received JZG(6 g each time,twice a day).These patients in the two groups received treatment for 6 weeks.Before treatment,at the end of the 4 th week of treatment,and at the end of the 6 th week of treatment,respectively,the severity of depression and anxiety of the patients in the two groups was assessed by using the Hamilton depression scale(HAMD)and the Hamilton anxiety scale(HAMA).During treatment,these patients were asked and examined actively to evaluate adverse reactions related to drugs.Results During follow-up,2 patients in the observation group and 4 patients in the control group failed to complete the treatment process due to their own(busy with their studies)or family reasons,and hence they were excluded from the study.These patients were not counted in the statistical analysis.Eventually,29 patients in the control group and 31 patients in the observation group completed the study and were included in the efficacy analysis.Before treatment,there was no significant difference in the HAMD and HAMA scores of patients between the two groups(P>0.05).At the 4 th and 6 th weekend of treatment,the HAMD and HAMA scores of patients in the two groups were significantly lower than those before treatment(P<0.05).At the 6 th weekend of treatment,the HAMD and H

关 键 词：焦虑性抑郁症 九味镇心颗粒 盐酸曲唑酮片 青少年 

分 类 号：R749[医药卫生—神经病学与精神病学]