抗性淀粉影响帕金森病可能作用机制的研究进展  

Research progress on the possible function mechanism of resistant starch impacting Parkinson’s disease

作　　者：李阳[1] 陈江瑛 LI Yang;CHEN Jiangying(Department of Neurology,Guangzhou Red Cross Hospital Affiliated to Jinan University,Guangdong,Guangzhou 510220,China)

机构地区：[1]暨南大学附属广州红十字会医院神经内科,广东广州510220

出　　处：《中国医药科学》2025年第1期31-34,共4页China Medicine And Pharmacy

基　　金：广东省广州市科技计划项目(2023A03J0575)。

摘　　要：帕金森病(PD)是第二大神经退行性疾病,已成为构成重大社会问题和经济威胁的中枢神经系统疾病之一。但由于其发病机制尚未完全清楚,临床上缺乏阻止病情发展及治愈PD的药物。随着人们对于健康的重视不断提高,一种全新的饮食疗法正在构建,它是基于增加抗性淀粉(RS)摄入,进而改变肠道微生物群,从而导致微生物产生短链脂肪酸的增加,并刺激肠道细胞分泌胰高血糖素样肽1(GLP-1)。本文现全面阐述RS改善PD症状的可能作用机制,并展望其在未来PD预防和治疗中的应用前景。Parkinson’s disease(PD)is the second largest neurodegenerative disease,and it has become one of the central nervous system diseases that pose a major social problem and economic threat.However,because its pathogenesis is not completely clear,there is a lack of drugs to prevent the development of the disease and cure PD in clinic.With people’s increasing attention to health,a brand-new diet therapy is being constructed,which is based on increasing the intake of resistant starch(RS),thus changing the intestinal microflora,leading to the increase of short-chain fatty acids produced by microorganisms and stimulating intestinal cells to secrete glucagon-like peptide-1(GLP-1).The possible function mechanism of RS is comprehensively expounded in improving PD symptoms in this paper,and its application prospect is envisioned in the prevention and treatment of PD in the future.

关 键 词：帕金森病 抗性淀粉 短链脂肪酸 胰高血糖素样肽1 

分 类 号：R742.5[医药卫生—神经病学与精神病学]