Immune skew of follicular helper T cells and effector T cells in patients with Sjögren’s syndrome  

作　　者：Xian Xiao Miao Miao Bo Huang Ruiling Feng Yuebo Jin Miao Shao Xia Zhang Jing Fang Wenbin Zhang Jing He 

机构地区：[1]Department of Rheumatology&Immunology,Peking University People’s Hospital,Beijing 100044,China [2]Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis(BZ0135),Beijing 100044,China [3]Beijing National Laboratory for Molecular Sciences,College of Chemistry and Molecular Engineering,Peking University,Beijing 100871,China [4]Key Laboratory of Polymer Chemistry&Physics of Ministry of Education,Center for Soft Matter Science and Engineering,Peking University,Beijing 100871,China.

出　　处：《Chinese Medical Journal》2024年第20期2518-2520,共3页中华医学杂志(英文版)

基　　金：supported by grants from the National Key R&D Program of China(Nos.2022YFE0131700 and 2022YFC3602000);the National Natural Science Foundation of China(No.82071813);the Beijing SciTech Program(No.Z191100006619114);Clinical Medicine Plus X-Young scholars Project of Peking University(No.PKU2020LCXQ018).

摘　　要：To the Editor:Primary Sjögren’s syndrome(pSS)is a chronic autoimmune disease characterized by the infiltration of lymphocytes into dysfunctional exocrine glands.Since the inhibition of lymphotoxin(LT)in the initial stages of pSS can significantly impede lymphocyte infiltration into the glands,early therapeutic intervention becomes more essential.[1]Therefore,it is critical for physicians to recognize and diagnose pSS at an early stage to ensure prompt and effective treatment.Previous study discovered that excessive follicular helper T(Tfh)cells supported autoantibody production in several autoimmune diseases.[2]Our previous study showed that activation of Tfh is positively associated with higher titers of autoantibodies and more severe manifestation in systemic lupus erythematosus(SLE)patients.The pathogenesis role of Tfh cells in autoimmune diseases has been verified.[3]However,the results from pSS studies were inconsistent and controversial.To provide support for further research in pSS,this study focused on describing the profile of the main T helper cells,particularly Tfh cells,in patients with active pSS.

关 键 词：PATIENTS AUTOIMMUNE IMMUNE 

分 类 号：R59[医药卫生—内科学]