Can exercise benefits be harnessed with drugs?A new way to combat neurodegenerative diseases by boosting neurogenesis  

作　　者：Renqing Zhao 

机构地区：[1]College of Physical Education,Yangzhou University,88 South Daxue Road,Yangzhou 225009,China

出　　处：《Translational Neurodegeneration》2024年第1期575-602,共28页转化神经变性病(英文)

摘　　要：Adult hippocampal neurogenesis(AHN)is affected by multiple factors,such as enriched environment,exercise,ageing,and neurodegenerative disorders.Neurodegenerative disorders can impair AHN,leading to progressive neuronal loss and cognitive decline.Compelling evidence suggests that individuals engaged in regular exercise exhibit higher production of proteins that are essential for AHN and memory.Interestingly,specific molecules that mediate the effects of exercise have shown effectiveness in promoting AHN and cognition in different transgenic animal models.Despite these advancements,the precise mechanisms by which exercise mimetics induce AHN remain partially understood.Recently,some novel exercise molecules have been tested and the underlying mechanisms have been proposed,involving intercommunications between multiple organs such as muscle-brain crosstalk,liver-brain crosstalk,and gut-brain crosstalk.In this review,we will discuss the current evidence regarding the effects and potential mechanisms of exercise mimetics on AHN and cognition in various neurological disorders.Opportunities,challenges,and future directions in this research field are also discussed.

关 键 词：Exercise mimetics Neurological diseases NEUROGENESIS COGNITION 

分 类 号：R741[医药卫生—神经病学与精神病学]