芝麻酚的生物学功能及其在抗肿瘤中作用  

Biological Functions of Sesamol and Its Role in Antitumor Activity

作　　者：蔡雅慧 李艳平 魏晓楠 CAI Ya-Hui;LI Yan-Ping;WEI Xiao-Nan(Clinical Medical College,Jining Medical University,Jining 272067,Shandong,China;Characteristic Laboratory of Precision Medicine for Chronic and Non-communicable Diseases of Shandong Province,Institute of Precision Medicine,Jining Medical University,Jining 272067,Shandong,China)

机构地区：[1]济宁医学院临床医学院,山东济宁272067 [2]济宁医学院精准医学研究院,山东省慢性非传染性疾病精准医学特色实验室,山东济宁272067

出　　处：《中国生物化学与分子生物学报》2025年第1期105-111,共7页Chinese Journal of Biochemistry and Molecular Biology

基　　金：国家自然科学基金项目(No.82002961);济宁医学院大学生创新训练计划项目(No.cx2023141z)资助。

摘　　要：芝麻酚是一种脂溶性的天然多酚化合物,存在于芝麻和芝麻油中,在食品中得到广泛应用。芝麻酚能有效清除体内自由基,减轻氧化应激,保护细胞免受损伤,在预防心血管疾病、癌症及神经退行性疾病中具有重要作用。因其具有抗氧化、抗菌、抗炎、保护神经、保护心血管、免疫调节和抗肿瘤等多种药理功能而被广泛研究。近年来,芝麻酚作为一种安全和无毒的化学物质,在肿瘤研究领域受到广泛关注并有望将来用于肿瘤治疗临床药物。本文通过对国内外芝麻酚的相关文献收集与分析,综述了芝麻酚在抗氧化、抗炎、抗菌、调节能量代谢、保护心血管、保护神经等多种生物学功能及其作用机制,并重点阐述了芝麻酚通过调节细胞能量代谢、诱导细胞凋亡、阻断细胞周期、调控表观遗传修饰、促进细胞自噬、抑制血管生成、降低化疗药物的耐受性等生理功效来发挥抗肿瘤作用,为肿瘤治疗药物研发提供了新的理论依据,以期为研究者开发肿瘤治疗药物提供新思路。Sesamol is a fat-soluble natural polyphenol compound found in sesame seeds and sesame oil,which is widely used in food.Sesamol can effectively scavenge free radicals in the body,reduce oxidative stress,and protect cells from damage,therefore it plays an important role in the prevention of cardiovascular disease,cancer and neurodegenerative diseases.It has been widely studied for its various pharmacological functions such as antioxidant,antibacterial,anti-inflammatory,neuroprotective,cardioprotective,immunomodulatory and antitumor.In recent years,sesamol,as a safe and non-toxic chemical substance,has received extensive attention in the field of tumor research and is expected to be used as a clinical drug for tumor therapy in the future.In this paper,through the collection and analysis of relevant literature on sesamol at home and abroad,we reviewed the biological functions of sesamol in antioxidant,anti-inflammatory,antibacterial,regulating energy metabolism,cardiovascular protection,and neuroprotection,etc.as well as its mechanism of action.Furthermore,this review also focused on the role of sesamol in regulating cellular energy metabolism,inducing apoptosis,blocking the cell cycle,modifying epigenetic modifications,promoting cellular autophagy,inhibiting angiogenesis,reducing the tolerance of chemotherapeutic drugs,and so on.In addition,this paper also focused on the anti-tumor effects of sesamol by regulating cell energy metabolism,inducing cell apoptosis,modulating epigenetic modification,promoting cell autophagy,inhibiting angiogenesis,and reducing the tolerance of chemotherapeutic drugs,etc.This review aims to provide a new theoretical basis for the development of tumor therapeutic drugs.

关 键 词：芝麻酚 多酚化合物 肿瘤治疗 

分 类 号：Q946[生物学—植物学]