Obesogenic effects of six classes of emerging contaminants  

作　　者：Siying Wu Chaoyu Tong Jing Liu 

机构地区：[1]MOE Key Laboratory of Environmental Remediation and Ecosystem Health,College of Environmental and Resource Sciences,Zhejiang University,Hangzhou 310058,China

出　　处：《Journal of Environmental Sciences》2025年第5期252-272,共21页环境科学学报(英文版)

基　　金：supported by the National Key Research&Development Programof China,Ministry of Science and Technology(Nos.2022YFE0134900 and 2022YFC3703200);the Key Research and Development Programof Zhejiang Province,China(No.2024C03228);the National Nature Science Foundation of China(Nos.22376184 and 22076166).

摘　　要：There is growing concern about the concept that exposure to environmental chemicals may be contributing to the obesity epidemic.However,there is no consensus on the obesogenic effects of emerging contaminants from a toxicological and environmental perspective.The potential human exposure and experimental evidence for obesogenic effects of emerging contaminants need to be systematically discussed.The main objective of this review is to provide recommendations for further subsequent policy development following a critical analysis of the literature for humans and experimental animals exposed to emerging contaminants.This article reviews human exposure to emerging contaminants(with a focus on antimicrobials,preservatives,water and oil repellents,flame retardants,antibiotics and bisphenols)and the impact of emerging contaminants on obesity.These emerging contaminants have been widely detected in human biological samples.Epidemiological studies provide evidence linking exposure to emerging contaminants to the risks of obesity in humans.Studies based on animalmodels and adipose cells show the obesogenic effects of emerging contaminants and identify modes of action by which contaminants may induce changes in body fat accumulation and lipid metabolic homeostasis.Some knowledge gaps in this area and future directions for further investigation are discussed.

关 键 词：Emerging contaminants OBESITY Human exposure PRESERVATIVES Flame retardants Plasticizers ANTIBIOTICS 

分 类 号：O62[理学—有机化学]