Comprehensive metabolic profiling of dioxin-like compounds exposure in laying hens:Implications for toxicity assessment  

作　　者：Xiaoxu Hu Tong Xu Yangsheng Chen Qian Zhang Lijuan Tang Liping Zheng Chu Wang Pu Wang Shujun Dong Ruiguo Wang Su Zhang Qinghua Zhang Heidi Qunhui Xie Li Xu Bin Zhao 

机构地区：[1]State Key Laboratory of Environmental Chemistry and Ecotoxicology,Research Center for Eco-Environmental Sciences,Chinese Academy of Sciences,Beijing 100085,China [2]University of Chinese Academy of Sciences,Beijing 100049,China [3]Department of Cardiology,Beijing Hospital,National Center of Gerontology,Beijing 100730,China [4]School of Environment,Hangzhou Institute for Advanced Study,University of Chinese Academy of Sciences,Hangzhou 310024,China [5]Hubei Key Laboratory of Industrial Fume and Dust Pollution Control,School of Environment and Health,Jianghan University,Wuhan 430056,China [6]Institute of Quality Standards and Testing Technology for Agro-Products,Chinese Academy of Agricultural Sciences,Beijing 100081,China

出　　处：《Journal of Environmental Sciences》2025年第2期107-115,共9页环境科学学报(英文版)

基　　金：supported by the National Key Research and Development Program of China (Nos.2018YFA0901101,2018YFA0901103,and 2017YFC1600301);the National Natural Science Foundation of China (Nos.22076216,21976201,and 21836004).

摘　　要：The evaluation of toxicity related to polychlorinated dibenzo-p-dioxins and furans(PCDD/Fs)and dioxin-like polychlorinated biphenyls(DL-PCBs)is crucial for a comprehensive risk assessment in real-world exposure scenarios.This study employed a controlled feeding experiment to investigate the metabolic effects of dioxin-like compounds(DLCs)on laying hens via feed exposure.Diets enriched with two concentrations(1.17 and 5.13 pg toxic equivalents(TEQ)/g dry weight(dw))were administered over 14 days,followed by 28 days of clean feed.Metabolomics analyses of blood samples revealed significant metabolic variations between PCDD/Fs and DL-PCBs exposed groups and controls,reflecting the induced metabolic disruption.Distinct changes were observed in sphingosine,palmitoleic acid,linoleate,linolenic acid,taurocholic acid,indole acrylic acid,and dibutyl phthalate levels,implying possible connections between PCDD/Fs and DL-PCBs toxic effects and energy-neuronal imbalances,along with lipid accumulation and anomalous amino acid metabolism,impacting taurine metabolism.Moreover,we identified three differential endogenous metabolites—L-tryptophan,indole-3-acetaldehyde,and indole acrylic acid—as potential ligands for the aryl hydrocarbon receptor(AhR),suggesting their role inmediating PCDD/Fs and DL-PCBs toxicity.This comprehensive investigation provides novel insights into the metabolic alterations induced by PCDD/Fs and DL-PCBs in laying hens,thereby enhancing our ability to assess risks associated with their exposure in human populations.

关 键 词：Polychlorinated dibenzo-p-dioxins and furans Dioxin-like polychlorinated BIPHENYLS Laying hens METABOLOMIC 

分 类 号：O62[理学—有机化学]