基于液相色谱-串联高分辨质谱技术的食品中污染物检测技术研究进展  

Research progress on determination of pollutants in food by liquid chromatography-high resolution mass spectrometry

作　　者：苏敏 李红丽 白亚敏 黄大亮 刘元 吴彦蕾 SU Min;LI Hong-Li;BAI Ya-Min;HUANG Da-Liang;LIU Yuan;WU Yan-Lei(Chongqing Institute for Food and Drug Control,Key Laboratory of Condiment Supervision Technology,State Administration for Market Regulation,Chongqing 401121,China)

机构地区：[1]重庆市食品药品检验检测研究院,国家市场监督管理总局重点实验室(调味品监管技术),重庆401121

出　　处：《食品安全质量检测学报》2025年第4期44-52,共9页Journal of Food Safety and Quality

基　　金：重庆市市场监督管理局科研计划项目(CQSJKJDW2023035,CQSJKJDW2024037)。

摘　　要：食品中污染物种类繁多,且暴露涉及食品原料、加工、运输、储藏、包装和销售等多个环节,随着人们对食品健康营养安全需求的提高,食品中的污染物问题受到越来越多的关注。液相色谱-串联高分辨质谱(liquid chromatography-high resolution mass spectrometry,LC-HRMS)技术结合了液相色谱的分离能力和高分辨质谱的质量范围宽、扫描速度快、灵敏度高等优点,成为食品安全分析领域的重要手段。本文综述了四极杆/飞行时间质谱、四极杆/静电场轨道阱质谱技术的特点以及近5年来LC-HRMS技术在食品中污染物检测方面的研究进展,重点讨论了LC-HRMS靶向、非靶向测定食品中农药残留、兽药及其代谢物、非法添加物、食品添加剂、毒素等方面的应用,并对其未来发展趋势进行了展望,旨在为今后食品中污染物的检测提供参考。There are many types of pollutants in food,and exposure involves multiple stages such as raw material,processing,transportation,storage,packaging,and sales.With the improvement of people’s requirements for the healthy,nutritive and safe condiments,the pollutants in food have received more and more attention.Liquid chromatography-high resolution mass spectrometry(LC-HRMS)combines the separation ability of liquid chromatography with the advantages of high resolution mass spectrometry,such as wide mass range,fast scanning speed,and high sensitivity,making it an important means in the field of food safety analysis.This review summarized the technical characteristics of quadrupole-time of flight mass spectrometry and quadrupole-orbitrap mass spectrometry,as well as the research progress in the detection of pollutants in food using LC-HRMS technology over the past 5 years.The article focused on the application of LC-HRMS in the targeted and non-targeted determination of pesticides residues,veterinary drugs and their metabolites,food additives,illegal additives and mycotoxins,and prospected the development trend.Aiming to provide reference for the detection of pollutants in food in the future.

关 键 词：液相色谱-串联高分辨质谱技术 农药残留 兽药及其代谢物 非法添加物 食品添加剂 毒素 

分 类 号：TS2[轻工技术与工程—食品科学与工程]