遗传因素在大动脉粥样硬化青年卒中中的作用研究进展  

Role of genetic factors in large atherosclerotic stroke in young adults

作　　者：黄娟 李小波[1] 陈益伟[1] 江芷仪 龙攀遥 袁毅[1] 胡舜通 Huang Juan;Li Xiaobo;Chen Yiwei;Jiang Zhiyi;Long Panyao;Yuan Yi;Hu Shuntong(Department of Neurology,the Third Xiangya Hospital of Central South University,Changsha 410013,China)

机构地区：[1]中南大学湘雅三医院神经内科,长沙410013

出　　处：《中华神经科杂志》2025年第2期210-219,共10页Chinese Journal of Neurology

基　　金：国家自然科学基金(82101529);湖南省自然科学基金(2023JJ40891);湖南省重点领域研发计划(2023SK2037,2023SK2006);中南大学湘雅三医院“汇智育才计划”(YX202213)。

摘　　要：青年卒中常有遗传因素参与其发病,其亚型——大动脉粥样硬化型可能是由多种遗传和环境因素共同引起,但人们对其潜在的发病机制知之甚少。文中阐述了遗传因素在动脉粥样硬化及相关危险因素中的作用,探究了大动脉粥样硬化型青年卒中可能的遗传机制。在未来的科研中,也许可以从青年卒中病因分型及相关遗传机制,可改变的血管危险因素及二级预防策略的制定,高分辨磁共振血管成像在青年卒中病因分型及早发性动脉粥样硬化、易损斑块等的发病机制等方面进一步研究,以便为更好地了解识别相关卒中病因遗传学因素及采取有效的预防策略提供线索。Genetic factors are often involved in the pathogenesis of young adult stroke,and its subtype,atherosclerotic type of large arteries,may be caused by a combination of genetic and environmental factors,but little is known about its underlying pathogenesis.To provide clues for better understanding of identifying relevant stroke etiological genetic factors and adopting effective preventive strategies,the role of genetic factors in atherosclerosis and related risk factors was described,and the possible genetic mechanisms of large-artery atherosclerotic stroke in young people were explored,which may be further investigated in future research in the following areas:etiological typing of stroke in young people and the related genetic mechanisms;modifiable vascular risk factors and the development of secondary prevention strategies;high-resolution vascular imaging magnetic resonance imaging in the etiological typing of stroke in young people and the pathogenesis of premature atherosclerosis and vulnerable plaques.

关 键 词：卒中 成年人 动脉粥样硬化 遗传学 多态性 单核苷酸 

分 类 号：R743.3[医药卫生—神经病学与精神病学]