Exploring the Protective Effects of Xueshuantong Injection on Central Retinal Vein Occlusion  

作　　者：Qiang Chen Jing Zhang Xin-Yu Liu Kai Xu Hui-Yi Guo Ya-Min Li Yu-Qing Guo Li-Na Liang 

机构地区：[1]Laboratory of Eye Function,China Academy of Chinese Medical Sciences Eye Hospital,Beijing,China

出　　处：《World Journal of Traditional Chinese Medicine》2024年第4期548-560,共13页世界中医药杂志(英文)

基　　金：supported by the National Natural Science Foundation of China (81973912,82274589);China Academy of Chinese Medical Sciences Innovation Fund (CI2021A02602);Central High-Level Traditional Chinese Medicine Hospital Project of Eye Hospital,China Academy of Chinese Medical Science (GSP5-32);Capital's Funds for Health Improvement and Research (2020-2-4183)

摘　　要：Objective:This study aimed to assess the therapeutic effects of Xueshuantong(XST),a traditional Chine se medicine that has been studied for its protective effects on the cardiovascular system and anti-inflammatory properties,on central retinal vein occlusion(CRVO) in rabbits and rats.Materials and Methods:CRVO was induced in rabbits and rats by laser photocoagulation.The animals were then treated with different do ses of XST or lyophilized XST(L).Color fundus photography,fundus fluorescein angiography,histological examination,TUNEL assay,and immunofluorescence staining were conducted to evaluate the therapeutic effects.Results:The study revealed that both XST and lyophilized XST inj ections exhibited therapeutic effects against CRVO in rabbits and rats.The drugs improved retinal le sions and structure and mitigated apoptosis of retinal cells to varying degrees.Additionally,downregulation of tumor necrosis factor-α and interleukin-6 within the retina was observed in both drug groups.Conclusions:The re sults indicate that XST injection exhibited significant protective effects against expe rimental CRVO by regulating angiogenesis and inflammation,suggesting its potential as an effective therapeutic strategy for treating CRVO.

关 键 词：ANGIOGENESIS central retinal vein occlusion INFLAMMATION protective effects Xueshuantong injection 

分 类 号：R285.5[医药卫生—中药学]