Brain injury biomarkers and applications in neurological diseases  

作　　者：Han Zhang Jing Wang Yang Qu Yi Yang Zhen-Ni Guo 

机构地区：[1]Stroke Center,Department of Neurology,the First Hospital of Jilin University,Changchun,Jilin 130021,China [2]Neuroscience Research Center,Department of Neurology,the First Hospital of Jilin University,Changchun,Jilin 130021,China

出　　处：《Chinese Medical Journal》2025年第1期5-14,共10页中华医学杂志(英文版)

基　　金：supported by the National Natural Science Foundation of China(No.81971105);the Science and Technology Department of Jilin Province(No.YDZJ202201ZYTS677);the Norman Bethune Health Science Center of Jilin University(No.2022JBGS03);Science and Technology Department of Jilin Province(Nos.YDZJ202302CXJD061 and 20220303002SF);Jilin Provincial Key Laboratory(No.YDZJ202302CXJD017).

摘　　要：Neurological diseases are a major health concern,and brain injury is a typical pathological process in various neurological disorders.Different biomarkers in the blood or the cerebrospinal fluid are associated with specific physiological and pathological processes.They are vital in identifying,diagnosing,and treating brain injuries.In this review,we described biomarkers for neuronal cell body injury(neuron-specific enolase,ubiquitin C-terminal hydrolase-L1,αII-spectrin),axonal injury(neurofilament proteins,tau),astrocyte injury(S100β,glial fibrillary acidic protein),demyelination(myelin basic protein),autoantibodies,and other emerging biomarkers(extracellular vesicles,microRNAs).We aimed to summarize the applications of these biomarkers and their related interests and limits in the diagnosis and prognosis for neurological diseases,including traumatic brain injury,status epilepticus,stroke,Alzheimer’s disease,and infection.In addition,a reasonable outlook for brain injury biomarkers as ideal detection tools for neurological diseases is presented.

关 键 词：Brain injury Biomarkers EPILEPSY Neurological diseases STROKE 

分 类 号：R741[医药卫生—神经病学与精神病学]