Advancements in conventional cancer therapy combined with immunotherapy  

作　　者：Hongxia Li Songyan Han Chunbo Dong Zhida Liu 

机构地区：[1]Third Hospital of ShanxiMedical University,Shanxi Bethune Hospital,Shanxi Academy of Medical Science,Tongji Shanxi Hospital,Taiyuan 030032,China [2]Shanxi Academy of Advanced Research and Innovation,Taiyuan 030032,China [3]Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital,Chinese Academy of medical Sciences/Cancer Hospital Affiliated to Shanxi medical University,Taiyuan 030013,China

出　　处：《Oncology and Translational Medicine》2025年第1期17-28,共12页肿瘤学与转化医学(英文版)

基　　金：supported by the National Science Foundation of China(No.82172726);the Youth Project of Science and Technology Department of Shanxi Province(No.202203021212105);the Research Project Supported by the Shanxi Scholarship Council of China(2021-156).

摘　　要：Conventional therapies are primary cancer treatments that directly eliminate or inhibit the growth of tumor cells,reducing the overall tumor burden.Increasing evidence suggests that conventional therapies possess significant immunomodulatory properties in addition to their established direct tumoricidal effects.Emerging immunotherapies have revolutionized the clinical management of various cancer types.Conventional therapy and immunotherapy have demonstrated remarkable clinical efficacy,leading to numerous ongoing clinical investiga-tions exploring their potential synergistic effects.However,trials investigating the combination of conventional therapy and immunotherapy have shown limited synergistic therapeutic efficacy.This unsatisfactory clinical outcome may be attributed to the suboptimal design of the combination approach and the inadequate understanding of the mechanisms and impacts of radiotherapy,chemotherapy,targeted ther-apy regimens(including dosing,timing,and administration route),and surgery on both cancer cells and the host immune system.Here,we comprehensively review preclinical and clinical investigations exploring the therapeutic effects and mechanisms of conventional therapy alone or in combination with immunotherapy.We proposed that optimizing the dosing,timing,and route of administration of conventional therapies can enhance the synergistic efficacy of combination therapies,thus offering significant clinical advantages.

关 键 词：Conventional therapy Tumor microenvironment IMMUNOTHERAPY Combinational therapy 

分 类 号：R73[医药卫生—肿瘤]