Clinical Significance of Alpha-Fetoprotein Levels in Artificial Liver Therapy for Liver Failure  

作　　者：Xiju Guo Weibo Guo Luyao Wang Yongping Wang Mingmei Liao Yingshan Liao 

机构地区：[1]Department of Gastroenterology,Baoshan People’s Hospital of Yunnan Province,Baoshan 678000,Yunnan Province,China [2]Department of Gastroenterology,Second Affiliated Hospital of Kunming Medical University,Kunming 650000,Yunnan Province,China [3]Kunming City Maternity and Child Health Hospital,Kunming 650118,Yunnan Province,China

出　　处：《Journal of Clinical and Nursing Research》2025年第1期305-313,共9页临床护理研究(英文)

摘　　要：Objective: Through the treatment of liver failure using artificial liver plasma exchange (PE), this study aims to explore the predictive value and clinical significance of alpha-fetoprotein (AFP) levels in the prognosis of liver failure patients. Methods: A retrospective analysis was conducted on the clinical data of 96 liver failure patients, all of whom underwent artificial liver plasma exchange therapy in addition to standard medical treatment. Based on AFP test values, patients were divided into three groups: low AFP group (AFP < 100 ng/mL, n = 32), medium AFP group (100 ≤ AFP < 200 ng/mL, n = 32), and high AFP group (AFP ≥ 200 ng/mL, n = 32). Serum AFP levels were measured before artificial liver therapy (on the second day of hospitalization), on days 1, 10, and 20 after treatment, and at the final evaluation (before discharge or prior to death) to observe changes. Results: Among the 96 patients, 4 (4.2%) had acute liver failure (ALF), 7 (7.3%) had subacute liver failure (SALF), 57 (59.4%) had acute-on-chronic liver failure (ACLF), and 28 (29.2%) had chronic liver failure (CLF), with an overall survival rate of 82.3% (79/96). Patients in the AFP < 100 ng/mL group had a lower survival rate compared to the other two groups, and survival rates increased with higher AFP levels (P < 0.05). Conclusion: Serum AFP levels are closely related to the efficacy of artificial liver plasma exchange therapy for liver failure, and dynamic monitoring of AFP changes can help assess disease progression.

关 键 词：ALPHA-FETOPROTEIN Artificial liver support system Plasma exchange Liver failure prognosis Hepatocyte regeneration 

分 类 号：R73[医药卫生—肿瘤]