Synergistic Inhibition of Nasopharyngeal Carcinoma by Biyan Qingdu Granule and Micro-Radiation:An Experimental Study  

作　　者：Ziye Shi Juan Lin Xiaofei Wang Keyi Xu Mengmeng Wang Bing Yang Xu Xu Peng Li 

机构地区：[1]Graduate School,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China [2]Guangzhou Baiyunshan Hutchison Whampoa Chinese Medicine Co.,Ltd.,Guangzhou 510515,China [3]Tianjin Key Laboratory of Quality Marker of Traditional Chinese Medicine,Institute of Pharmaceutical Research,Tianjin 300301,China [4]National and Local Joint Engineering Laboratory of Modern Preparation and Quality Control Technology,Institute of Pharmaceutical Research,Tianjin 300301,China

出　　处：《Proceedings of Anticancer Research》2024年第6期105-112,共8页抗癌研究

基　　金：Guangzhou Science and Technology Planning Project(Project no.20212210006)。

摘　　要：Objective: To investigate the role of Biyan Qingdu Granule combined with micro-radiation in suppressing nasopharyngeal carcinoma and to explore its mechanism of action. Methods: FAT cells of nasopharyngeal carcinoma were injected into the hind limb axilla of F344 rats to establish a rat nasopharyngeal carcinoma tumor model. X-ray radiation was applied to the oral cavity of the rats, delivering a micro-dose of radiation to the distant hind limb axilla tumor. The general condition of the rats, including oral mucosal inflammation, the size of the nasopharyngeal tumor mass, pathological changes in the tumor tissue, and the levels of TNF-α, IL-1β, IL-6, IL-18, IL-12, ICAM-1, and VCAM-1 in the tumor tissue, were assessed. Results: Oral administration of Biyan Qingdu Granule improved the rats’ overall condition and reduced oral mucosal inflammation. Pathological examination revealed tumor cell degeneration and necrosis. ELISA analysis of tumor tissue showed significant reductions in TNF-α, IL-1β, IL-6, ICAM-1, and VCAM-1 levels, along with a notable increase in IL-18 levels. Conclusion: Biyan Qingdu Granule, when combined with micro-radiation, can inhibit tumor growth and reduce tumor volume. Its mechanism of action may involve enhancing immune function and suppressing inflammatory factors.

关 键 词：Biyan Qingdu Granule Nasopharyngeal carcinoma RADIOTHERAPY Tumor necrosis factor INTERLEUKIN Vascular endothelial cell adhesion molecule 

分 类 号：R73[医药卫生—肿瘤]