Update on the roles and applications of extracellular vesicles in depression  

作　　者：Jing Wu Jian Lu Ming-Zhi Pan Xiao-Chu Gu Lu Dai Yun Wang Bin Shen Xiao-Bin Zhang 

机构地区：[1]Laboratory Medicine,The Affiliated Guangji Hospital of Soochow University,Suzhou 215137,Jiangsu Province,China [2]Laboratory Medicine,The Second Affiliated Hospital of Soochow University,Suzhou 215000,Jiangsu Province,China [3]Department of Psychiatry,Suzhou Psychiatric Hospital,Institute of Mental Health,The Affiliated Guangji Hospital of Soochow University,Suzhou 215137,Jiangsu Province,China

出　　处：《World Journal of Psychiatry》2025年第3期32-48,共17页世界精神病学杂志(英文)

基　　金：Supported by Gusu Talent program,No.(2023)105;Suzhou Science and Technology Development Plan Program,No.SKY2023228;Project of Medical Research Fund of Jiangsu Provincial Health Commission,No.Z2023043;Suzhou Clinical Medical Center for Mood Disorders,No.Szlcyxzx202109;Suzhou Clinical Key Disciplines for Geriatric Psychiatry,No.SZXK202116.

摘　　要：Depression is a prevalent mental disorder that affects numerous individuals,manifesting as persistent anhedonia,sadness,and hopelessness.Despite extensive research,the exact causes and optimal treatment approaches for depression remain unclear.Extracellular vesicles(EVs),which carry biological molecules such as proteins,lipids,nucleic acids,and metabolites,have emerged as crucial players in both pathological and physiological processes.EVs derived from various sources exert distinct effects on depression.Specifically,EVs released by neurons,astrocytes,microglia,oligodendrocytes,immune cells,stem cells,and even bacteria contribute to the pathogenesis of depression.Moreover,there is growing interest in potential of EVs as diagnostic and therapeutic tools for depression.This review provides a comprehensive overview of recent research on EVs from different sources,their roles in depression,and their potential clinical applications.

关 键 词：DEPRESSION Extracellular vesicles EXOSOMES Biomarkers Different sources 

分 类 号：R749.3[医药卫生—神经病学与精神病学]