Comparison of endoscopic submucosal dissection and transanal endoscopic microsurgery for stage 1 rectal neuroendocrine tumors  

作　　者：Jun Weng Jun Chi Yan-Hua Lv Ruo-Bing Chen Guo-Liang Xu Xian-Feng Xia Kun-Hao Bai 

机构地区：[1]Department of Endoscopy,Sun Yat-sen University Cancer Center,Guangzhou 510060,Guangdong Province,China [2]Department of Colorectal Surgery,Sun Yat-sen University Cancer Center,Guangzhou 510060,Guangdong Province,China [3]Cancer Prevention Center,Sun Yat-sen University Cancer Center,Guangzhou 510060,Guangdong Province,China

出　　处：《World Journal of Gastrointestinal Endoscopy》2025年第2期7-15,共9页世界胃肠内镜杂志(英文)

基　　金：Supported by the Basic and Applied Basic Research Foundation of Guangzhou,No.202201011331;the National Natural Science Foundation of China,No.82373118;the Natural Science Foundation of Guangdong Province,No.2023A1515010828.

摘　　要：BACKGROUND Stage 1 rectal neuroendocrine tumors(NETs)are best treated with endoscopic submucosal dissection(ESD)or transanal endoscopic microsurgery(TEM)for local resection.AIM To investigate the safety and efficacy of ESD and TEM for local resection of stage 1 rectal NETs.METHODS This retrospective observational analysis included patients with clinical stage 1 rectal NETs(cT1N0M0,less than 20 mm)who underwent ESD or TEM.The ESD and TEM groups were matched to ensure that they had comparable lesion sizes,lesion locations,and pathological grades.We assessed the differences between groups in terms of en bloc resection rate,R0 resection rate,adverse event rate,recurrence rate,and hospital stay and cost.RESULTS Totally,128 Lesions(ESD=84;TEM=44)were included,with 58 Lesions within the matched groups(ESD=29;TEM=29).Both the ESD and TEM groups had identical en bloc resection(100.0%vs 100.0%,P=1.000),R0 resection(82.8%vs 96.6%,P=0.194),adverse event(0.0%vs 6.9%,P=0.491),and recurrence(0.0%vs 3.4%,P=1.000)rates.Nevertheless,the median hospital stay[ESD:5.5(4.5-6.0)vs TEM:10.0(7.0-12.0)days;P<0.001],and cost[ESD:11.6(9.8-12.6)vs TEM:20.9(17.0-25.1)kilo-China Yuan,P<0.001]were remarkably shorter and less for ESD.CONCLUSION Both ESD and TEM were well-tolerated and yielded favorable outcomes for the local removal of clinical stage 1 rectal NETs.ESD exhibits shorter hospital stay and fewer costs than TEM.

关 键 词：Rectal neuroendocrine tumors Endoscopic submucosal dissection Transanal endoscopic microsurgery SAFETY EFFICACY 

分 类 号：R735.37[医药卫生—肿瘤]