Role of triggering receptor expressed on myeloid cells 2 in the pathogenesis of non-alcoholic fatty liver disease  

作　　者：Li-Hui Zhang Su-Tong Liu Qing Zhao Xiao-Yan Liu Tong Liu Qiang Zhang Ming-Hao Liu Wen-Xia Zhao 

机构地区：[1]Department of Spleen,Stomach and Hepatobiliary Diseases,The First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000,Henan Province,China [2]Collaborative Innovation Center of Prevention and Treatment of Major Diseases by Chinese and Western Medicine,The First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000,Henan Province,China [3]Department of Spleen,Stomach,Liver and Gallbladder Diseases,The First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000,Henan Province,China

出　　处：《World Journal of Hepatology》2025年第2期31-46,共16页世界肝病学杂志(英文)

基　　金：Supported by Henan Province's"Double First-Class"Creation of Scientific Research in Traditional Chinese Medicine,No.HSRPDFCTCM-2023-7-23 and No.STG-ZYX02-202117;National Traditional Chinese Medicine Clinical Research Base Scientific Research Special Project,No.2022JDZX098 and No.2022JDZX114;National Natural Science Foundation of China,No.82205086;The 9th China Association for Science and Technology Young Talent Support Project,No.2023QNRC001.

摘　　要：Non-alcoholic fatty liver disease(NAFLD)is a progressive disease.Without effective interventions,NAFLD can gradually develop to non-alcoholic steatohepatitis,fatty liver fibrosis,liver cirrhosis and even hepatocellular carcinoma.It is still to investigate the precise molecular mechanism behind the pathophysiology of NAFLD.Triggering receptor expressed on myeloid cells 2(TREM2)can sense tissue injury and mediate immune remodeling,thereby inducing phagocytosis,lipid metabolism,and metabolic transfer,promoting cell survival and combating inflammatory activation.NAFLD might develop as a result of TREM2's regulatory role.We here briefly summarize the biological characteristics of TREM2 and its functions in the disease progression of NAFLD.Moreover,we propose to broaden the therapeutic strategy for NAFLD by targeting TREM2.

关 键 词：Triggering receptor expressed on myeloid cells 2 Non-alcoholic fatty liver disease MACROPHAGE Lipid metabolism Inflammation 

分 类 号：R57[医药卫生—消化系统]