Survival of patients with hepatopulmonary syndrome related to cirrhotic and non-cirrhotic(schistosomiasis)portal hypertension  

作　　者：Melissa M Rolim Liana G Farsoun Carlos F Luna Brivaldo Markman-Filho Paulo Querette Edmundo P Lopes Ana L Domingues 

机构地区：[1]Postgraduate Program in Tropical Medicine,Center of Medical Sciences,Universidade Federal de Pernambuco,Recife 50670901,Pernambuco,Brazil [2]Faculdade de Medicina UniNassau,Grupo Ser Educacional,Recife 50100220,Pernambuco,Brazil [3]Statistics and Geoprocessing Center,Institute Aggeu Magalhães,Oswaldo Cruz Foundation,Recife 50740465,Pernambuco,Brazil [4]Department of Cardiology Division,Hospital das Clínicas/EBSERHUniversidade Federal de Pernambuco,Recife 50670901,Pernambuco,Brazil [5]Department of Internal Medicine,Center of Medical Sciences,Universidade Federal de Pernambuco,Recife 50670901,Pernambuco,Brazil [6]Postgraduate Program in Translational Health,Center of Medical Sciences,Universidade Federal de Pernambuco,Recife 50670901,Pernambuco,Brazil [7]Department of Gastroenterology Division,Hospital das Clínicas/EBSERH-Universidade Federal de Pernambuco,Recife 50670901,Pernambuco,Brazil

出　　处：《World Journal of Hepatology》2025年第2期65-71,共7页世界肝病学杂志(英文)

摘　　要：BACKGROUND The hepatosplenic schistosomiasis(HSS)with portal hypertension can cause vascular complications such as hepatopulmonary syndrome(HPS).HPS increases the risk of mortality in patients with cirrhosis;however,there is no data on the mortality of patients with HSS and HPS.AIM To perform a survival analysis of patients with HPS related to cirrhotic and non-cirrhotic(schistosomiasis)portal hypertension.METHODS From August 2023 to January 2024,medical records and the official mortality information service of 121 patients who participated in a cross-sectional study on HPS between 2010 and 2012 were analyzed.Survival curves were created using the Kaplan-Meier method,and comparisons were performed using the log-rank test.Cox regression models estimated the hazard ratios(HR).RESULTS Overall,data of 113 patients were analyzed;most(55.8%)had HSS and concomitant cirrhosis(HSS/cirrhosis).Meanwhile,HPS was present in 39(34.5%)patients.Death occurred in 65 patients[57.5%];95%confidence interval(CI):48%-67%.The average time to death was lower in those with HPS when compared to those without HPS(3.37 years vs 5.65 years;P=0.017).According to the cause of liver disease,patients with HSS/cirrhosis died earlier,and their risk of death was twice as high compared with patients with HSS without cirrhosis(HR:2.17;95%CI:1.3-3.60;P=0.003).Meanwhile,there were no differences when comparing the two groups with and without HPS(HR:1.01;95%CI:0.59-1.73;P=0.967).CONCLUSION Patients with HSS and concomitant cirrhosis had a lower survival rate,but there was no difference in survival regardless of the presence of HPS.

关 键 词：SCHISTOSOMIASIS Portal hypertension Hepatopulmonary syndrome SURVIVAL MORTALITY Non-cirrhotic portal hypertension 

分 类 号：R575[医药卫生—消化系统] R563[医药卫生—内科学]