Liver function linked to bone health:A bibliometric of the liver-bone axis  

作　　者：Wei-Jin Zhang Xun-Pei Xu Xin-Hua Song Zhan-Rong Zhang Xuan-Rui Zhang Biao Yang Zheng-Bo Tao Zheng Zhang Xu-Hui Zhou 

机构地区：[1]Department of Orthopedics,Changzheng Hospital,Second Military Medical University(Naval Medical University),Shanghai 200003,China [2]Department of Pharmacy,Changzheng Hospital,Second Military Medical University(Naval Medical University),Shanghai 200003,China [3]Department of Orthopedic Rehabilitation,Qingdao Special Servicemen Recuperation Center of People’s Liberation Army Navy,Qingdao 266000,Shandong Province,China [4]Translational Research Center of Orthopedics,Shanghai General Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 201600,China

出　　处：《World Journal of Hepatology》2025年第2期251-269,共19页世界肝病学杂志(英文)

基　　金：Supported by the National Natural Science Foundation of China,No.82172516 and No.82372434.

摘　　要：BACKGROUND The liver exerts profound influence on skeletal health,while osseous tissues reciprocally modulate hepatic function.This bidirectional metabolic axis between these two organ systems plays a pivotal role in both physiological homeostasis and pathological states.AIM To investigate and analyze the literatures on liver-bone axis using bibliometrics.METHODS A comprehensive literature search pertaining to the liver-bone axis was conducted using the Science Citation Index Expanded within the Web of Science Core Collection.Subsequently,visualization and bibliometric analyses were performed utilizing VOSviewer(version 1.6.20),Citespace(version 6.2.R4),and the R programming language.RESULTS This comprehensive analysis encompasses 855 publications,comprising 694 articles and 161 reviews,authored by 4988 researchers from 425 institutions across 61 countries.The United States and China emerge as the leading nations in terms of publication volume.The University of California system stands out as the most influential institution in liver-bone axis research.Guanabens N is identified as the most prolific author in this field.The annual increase in publications related to the liver-bone axis underscores its growing prominence as a research focus.The study highlights key areas of investigation,including osteoporosis,bone metabolism,non-alcoholic fatty liver disease,and insulin-like growth factor-1,which represent both current and prospective hot topics within this domain.CONCLUSION This investigation employs bibliometric methodologies to conduct a systematic analysis of liver-bone axis literature spanning from 2001 to 2024.The exponential growth in publications over the past two decades underscores the significance of synthesizing research outcomes in this domain.Through rigorous statistical analyses,we delineate fundamental contributions to the field while providing strategic direction for emerging scholars.Furthermore,we illuminate current research trajectories and identify promising future investigative directions.Inv

关 键 词：Non-alcoholic fatty liver disease Bone metabolism LIVER OSTEOPOROSIS CITESPACE VOSviewer 

分 类 号：R575[医药卫生—消化系统] G353.1[医药卫生—内科学]