Perioperative neurocognitive dysfunction and role of dexmedetomidine in radical colon cancer surgery in elderly patients  

作　　者：Chandra K Pandey Abhishek Kumar 

机构地区：[1]Department of Anaesthesiology,Medanta Hospital Lucknow,Lucknow 226030,Uttar Pradesh,India [2]Department of Anaesthesia,King George Medical University,Lucknow 226003,Uttar Pradesh,India

出　　处：《World Journal of Gastrointestinal Surgery》2025年第3期6-13,共8页世界胃肠外科杂志(英文)

摘　　要：This article explored the application of dexmedetomidine(Dex),a highly selective alpha-2 agonist,in managing postoperative cognitive dysfunction(POCD)in elderly patients undergoing radical colon cancer surgery.Aging is associated with a progressive decline in physiological functions and an increased risk of adverse surgical outcomes,including POCD,which encompasses many neurocognitive disorders that manifest during the perioperative period.The aging population is at a higher risk for POCD,which can lead to prolonged hospital stays,delayed recovery,and increased healthcare costs.Dex has neuroprotective,opioid-sparing,and sympatholytic properties,which reduces the incidence and severity of POCD.Dex was introduced for sedation in patients receiving mechanical ventilation but has since been adopted in anesthesia due to its multifaceted benefits.Its appli-cation extends to sedation,analgesia,maintenance of anesthesia,and controlling delirium.Its neuroprotective and anti-inflammatory effects have been explored in managing POCD.This article discussed the broad range of patient and procedure-related risk factors for POCD.Early identification and intervention are crucial to prevent the progression of POCD,which can have severe physical,psychological,and economic consequences.The article underscored the importance of a mul-tidisciplinary approach in managing POCD,involving the optimization of comor-bidities,depth of anesthesia monitoring,hemodynamic stability,and cerebral oxygenation monitoring.

关 键 词：Colon cancer DEXMEDETOMIDINE General anesthesia ELDERLY Radical colon cancer surgery Cognitive function 

分 类 号：R61[医药卫生—外科学]