Cannabis use disorder and severe sepsis outcomes in cancer patients:Insights from a national inpatient sample  

作　　者：Avinaash R Sager Rupak Desai Maneeth Mylavarapu Dipsa Shastri Nikitha Devaprasad Shiva N Thiagarajan Deepak Chandramohan Anshuman Agrawal Urmi Gada Akhil Jain 

机构地区：[1]Internal Medicine,St.Elizabeth’s Medical Center,Boston,MA 02135,United States [2]Outcomes Research,Independent Researcher,Atlanta,GA 30033,United States [3]Public Health,Adelphi University,Garden City,NY 11530,United States [4]Internal Medicine,East Tennessee State University,Johnson,TN 37614,United States [5]Internal Medicine,SRM Medical College Hospital and Research Center,Potheri 603211,India [6]Department of Nephrology,University of Alabama at Birmingham,Birmingham,AL 35001,United States [7]Internal Medicine,Kasturba Hospital,Manipal 576104,India [8]Infectious Diseases,Deenanath Hospital,Erandwane 411004,India [9]Department of Hematology and Medical Oncology,University of Iowa Hospitals and Clinics,Iowa,IA 52242,United States

出　　处：《World Journal of Critical Care Medicine》2025年第2期92-104,共13页世界重症医学杂志(英文)

摘　　要：BACKGROUND The burden of cannabis use disorder(CUD)in the context of its prevalence and subsequent cardiopulmonary outcomes among cancer patients with severe sepsis is unclear.AIM To address this knowledge gap,especially due to rising patterns of cannabis use and its emerging pharmacological role in cancer.METHODS By applying relevant International Classification of Diseases,Ninth and Tenth Revision,Clinical Modification codes to the National Inpatient Sample database between 2016-2020,we identified CUD(+)and CUD(-)arms among adult cancer admissions with severe sepsis.Comparing the two cohorts,we examined baseline demographic characteristics,epidemiological trends,major adverse cardiac and cerebrovascular events,respiratory failure,hospital cost,and length of stay.We used the Pearsonχ^(2) d test for categorical variables and the Mann-Whitney U test for continuous,non-normally distributed variables.Multivariable regression analysis was used to control for potential confounders.A P value≤0.05 was considered for statistical significance.RESULTS We identified a total of 743520 cancer patients admitted with severe sepsis,of which 4945 had CUD.Demographically,the CUD(+)cohort was more likely to be younger(median age=58 vs 69,P<0.001),male(67.9%vs 57.2%,P<0.001),black(23.7%vs 14.4%,P<0.001),Medicaid enrollees(35.2%vs 10.7%,P<0.001),in whom higher rates of substance use and depression were observed.CUD(+)patients also exhibited a higher prevalence of chronic pulmonary disease but lower rates of cardiovascular comorbidities.There was no significant difference in major adverse cardiac and cerebrovascular events between CUD(+)and CUD(-)cohorts on multivariable regression analysis.However,the CUD(+)cohort had lower all-cause mortality(adjusted odds ratio=0.83,95%confidence interval:0.7-0.97,P<0.001)and respiratory failure(adjusted odds ratio=0.8,95%confidence interval:0.69-0.92,P=0.002).Both groups had similar median length of stay,though CUD(+)patients were more likely to have higher hospital cost compared to CUD(-)patie

关 键 词：Cannabis/marijuana SEPSIS Cardiovascular outcomes Major adverse cardiac and cerebrovascular events Pulmonological complications Cancer 

分 类 号：R730.2[医药卫生—肿瘤]