Resveratrol and pancreatic cancers:Questions and future perspectives  

作　　者：Olga A Sukocheva 

机构地区：[1]Department of Gastroenterology and Hepatology,Royal Adelaide Hospital,Adelaide 5000,South Australia,Australia

出　　处：《World Journal of Gastrointestinal Oncology》2025年第3期9-12,共4页世界胃肠肿瘤学杂志(英文)

摘　　要：There is still no effective treatment for pancreatic cancer,one of the deadliest malignancies among the gastrointestinal diseases.Jiang et al demonstrated the presence of senescent cancer-associated fibroblasts(CAFs)in pancreatic cancer tissues,supporting the use of CAFs as potential anti-cancer targets.The study indicated that a natural plant-derived compound resveratrol can reverse senescent CAF phenotype and decrease the growth,migration,and invasiveness of pancreatic cancer cells.Notably,the study indicated that resveratrol might be involved in regulating epithelial-to-mesenchymal transition in the tumor microenvironment.This editorial shares insights on the future investigation of resveratrol signaling in cancer cells and the tumor microenvironment,and discusses resveratrol-based treatment perspectives.

关 键 词：Pancreatic cancer RESVERATROL Cancer-associated fibroblasts Tumor microenvironment ANTIOXIDANT Immune senescence 

分 类 号：R73[医药卫生—肿瘤]