Mapping the landscape of gastric cancer immunotherapy:Bibliometric insights into advances and hotspots  

作　　者：Zhen Yuan Jing-Hang Wang Hao Cui Shu-Yuan Wang Bo Wei Jian-Xin Cui 

机构地区：[1]School of Medicine,Nankai University,Tianjin 300071,China [2]Department of General Surgery,The First Medical Center,Chinese PLA General Hospital,Beijing 100853,China

出　　处：《World Journal of Gastrointestinal Oncology》2025年第3期349-370,共22页世界胃肠肿瘤学杂志(英文)

基　　金：National Natural Science Foundation of China,No.82073192 and No.82273231;Beijing Science and Technology Program,No.Z221100007422125;The Chinese People's Liberation Army General Hospital Medical Engineering Laboratory Project,No.2022SYSZZKY16.

摘　　要：BACKGROUND Immunotherapy has surfaced as a promising therapeutic modality for gastric cancer(GC).A comprehensive review of advancements,current status,and research trends in GC immunotherapy is essential to inform future investigative efforts.AIM To delineate the trends,advancements,and focal points in immunotherapy for GC.METHODS We performed a bibliometric analysis of 2906 articles in English concerning GC immunotherapy published from 2000 to December 20,2023,indexed in the Web of Science Core Collection.Data analysis and visualization were facilitated by CiteSpace(6.1.6R),VOSviewer v.1.6.17,and GraphPad Prism v8.0.2.RESULTS There has been an increase in the annual publication rate of GC immunotherapy research.China leads in publication volume,while the United States demonstrates the highest citation impact.Fudan University is notable for its citation frequency and publication output.Co-citation analysis and keyword frequency revealed and highlighted a focus on GC prognosis,the tumor microenvironment(TME),and integrative immunotherapy with targeted therapy.Emerging research areas include gastroesophageal junction cancer,adoptive immunotherapy,and the role of Treg cell in immunotherapy.CONCLUSION GC immunotherapy research is an expanding field attracting considerable scientific interest.With the clinical adoption of immunotherapy in GC,the primary goals are to enhance treatment efficacy and patient outcomes.Unlike hematological malignancies,GC's solid TME presents distinct immunological challenges that may attenuate the cytotoxic effects of immune cells on cancer cells.For instance,although CAR-T therapy is effective in hematological malignancies,it has underperformed in GC settings.Current research is centered on overcoming immunosuppression within the TME,with a focus on combinations of targeted therapy,adoptive immunotherapy,Treg cell dynamics,and precise prognosis prediction in immunotherapy.Additionally,immunotherapy's role in treating gastroesophageal junction cancer has become a novel research focus.

关 键 词：BIBLIOMETRICS Gastric cancer IMMUNOTHERAPY Immune checkpoint inhibitor Tumor microenvironment 

分 类 号：R73[医药卫生—肿瘤]