枇杷花多酚微胶囊的制备工艺及特性研究  

Studies on the Preparation Process and Characteristics of Loquat Flower Polyphenol Microcapsules

作　　者：刘芬芬 蒲首丞[1] 赵雯靓 徐丽珊[1,2] LIU Fenfen;PU Shoucheng;ZHAO Wenliang;XU Lishan(College of Life Sciences,Zhejiang Normal University,Jinhua 321004,Zhejiang;Zhejiang Provincial Key Laboratory of Biotechnology on Specialty Economic Plants,Jinhua 321004,Zhejiang)

机构地区：[1]浙江师范大学生命科学学院,浙江金华321004 [2]浙江省特色经济植物生物技术研究重点实验室,浙江金华321004

出　　处：《中国食品学报》2025年第1期208-218,共11页Journal of Chinese Institute Of Food Science and Technology

摘　　要：为提高枇杷花多酚的利用率及稳定性,采用果胶、海藻酸钠及壳聚糖为复合壁材,制备枇杷花多酚微胶囊。选取微胶囊包埋率及载药量为优化指标,通过单因素实验和响应面分析优化枇杷花多酚微胶囊的制备工艺,并对微胶囊的表观特性、体外缓释效果及稳定性进行评价。结果表明,大孔树脂富集后的枇杷花多酚具有较高的多酚含量及生物活性,可作为本试验芯材。果胶辅助包埋制备微胶囊的最佳制备工艺为:果胶与芯材质量比1∶2,海藻酸钠质量分数2.0%,壳聚糖质量分数0.19%,氯化钙质量分数1.5%,pH 5.9。此条件下制备的微胶囊包埋率为(86.98±0.25)%,载药量为(38.24±0.49)%,平均粒径为(4.92±0.74)μm,形态近似球状。模拟胃肠液消化6 h后,微胶囊在胃、肠液中累计释放率分别为19.59%和82.53%。此外,枇杷花多酚经微胶囊化处理,温度稳定性和光稳定性均有所提高,说明该工艺制备的微胶囊可以提高枇杷花多酚的缓释作用及稳定性,从而提高枇杷花多酚的利用率。In order to improve the utilization and stability of loquat flower polyphenols,pectin,sodium alginate and chitosan were used as composite wall materials to prepare loquat flower polyphenols microcapsules.The preparation process of loquat polyphenol microcapsules was optimized by single-factor test and response surface analysis,and the apparent properties,in vitro slow release effect and stability of the microcapsules were evaluated.The results showed that the loquat polyphenol enriched by macroporous resin had higher polyphenol content and biological activity,and was used as the core material of this experiment.The best preparation process of pectin assisted embedding for microcapsules was as follows:pectin to core material mass ratio 1∶2,sodium alginate mass fraction 2.0%,chitosan mass fraction 0.19%,calcium chloride mass fraction 1.5%,pH 5.9.Under these conditions,the embedding rate of microcapsules was(86.98±0.25)%,the drug loading was(38.24±0.49)%,the average particle size was(4.92±0.74)μm,and the shape was nearly spherical.After 6 h of simulated gastroenteric fluid digestion,the cumulative release rate of microcapsules in stomach and intestinal fluid was 19.59%and 82.53%,respectively.In addition,the temperature stability and light stability of loquat flower polyphenols were improved after microencapsulation.The microcapsules prepared by this process can improve the slow-release and stability of loquat flower polyphenols,and improve the utilization rate of loquat flower polyphenols.

关 键 词：枇杷花多酚 微胶囊 响应面法 缓释 稳定性 

分 类 号：TS2[轻工技术与工程—食品科学与工程]