阿魏酸对阿尔茨海默病的神经保护作用  

The neuroprotective properties of ferulic acid in Alzheimer's disease

作　　者：刘梦鸽 陈斯亮 冯玮琪 罗静怡 王欣欣 蔡红艳 韩维娜[1] LIU Mengge;CHEN Siliang;FENG Weiqi;LUO Jingyi;WANG Xinxin;CAI Hongyan;HAN Weina(Puai Medical College,Shaoyang University,Shaoyang 422000,China;School of Basic Medical Sciences,Shanxi Medical University,Taiyuan 030000,China)

机构地区：[1]邵阳学院普爱医学院,邵阳422000 [2]山西医科大学基础医学院,太原030000

出　　处：《生命的化学》2025年第1期55-64,共10页Chemistry of Life

基　　金：国家自然科学基金面上项目(82171428);湖南省自然科学基金青年项目(2020JJ5517);湖南省教育厅科学研究项目(20C1671);国家级大学生创新创业训练项目(S202010547043)。

摘　　要：阿尔茨海默病(Alzheimer’s disease,AD)是老年人最常见的疾病之一,发病率高,严重影响老年人生活质量,属于年龄相关的记忆和思维能力障碍的疾病。AD发病机制复杂,目前临床上尚无统一的结论和有效的治疗方法,因此找到新的治疗药物是目前有待解决的问题。研究发现,基于多酚饮食方式,可有效预防或减缓AD进展。阿魏酸(ferulic acid,FA)是一种羟基肉桂酸衍生物,属于多酚类化合物,广泛分布于自然界中,尤其是中草药、谷物麸皮和水果中。已知FA具有抗Aβ聚集、抗氧化和抗炎等多种生物作用。FA及其衍生物对AD动物和细胞模型都具有显著的治疗作用,可作为一种新的治疗AD的神经保护策略。本文主要对FA的各种生物作用进行综述,为进一步探寻FA治疗AD的机制提供参考。Alzheimer's disease(AD) is one of the most common diseases among the elderly,with a high incidence rate and a significant impact on the quality of life of older individuals.It is characterized by agerelated memory and cognitive impairments.The pathogenesis of AD is complex,and currently,there is no unified conclusion or effective treatment method in clinical practice.Therefore,finding new therapeutic drugs is an unresolved issue.Studies have found that a polyphenol-rich diet can effectively prevent or slow down the progression of AD.Ferulic acid is a hydroxycinnamic acid derivative,a polyphenolic compound widely distributed in nature,particularly in medicinal herbs,cereal bran and fruits.It is known to possess various biological activities,including anti-Aβ aggregation,antioxidant and anti-inflammatory effects.Ferulic acid and its derivatives have shown significant therapeutic effects in animal and cellular models of AD,making it a promising neuroprotective strategy for treating AD.This work provides a comprehensive review of the various biological effects of ferulic acid,serving as a reference for further exploration of the mechanisms underlying ferulic acid therapeutic effects in AD.

关 键 词：阿尔茨海默病 阿魏酸 Β-淀粉样蛋白 神经保护作用 

分 类 号：R749.16[医药卫生—神经病学与精神病学]