Breast relapse of myeloid sarcoma and SARS-CoV-2 infection following hematopoietic stem cell transplantation in mixed-phenotype acute leukemia: a case report  

作　　者：Chaolu Hu Hui Liu Song Zhao Mengmeng Shang Rong Ma Xiaoyuan Dong Jiang Zhu 

机构地区：[1]Department of Breast Surgery,General Surgery,Qilu Hospital of Shandong University,Jinan,Shandong,China [2]Department of Radiation Oncology,Qilu Hospital of Shandong University,Jinan,Shandong,China [3]Department of Ultrasound,Qilu Hospital of Shandong University,Jinan,Shandong,China [4]Department of Hematology,Qilu Hospital of Shandong University,Jinan,Shandong,China

出　　处：《Emergency and Critical Care Medicine》2024年第4期191-195,共5页急危重症医学(英文)

摘　　要：Background:Mixed-phenotype acute leukemia is a rare,high-risk subtype of acute leukemia.Myeloid sarcoma is a localized tumor formed by the proliferation and infiltration of primitive or immature myeloid cells outside the bone marrow.It is often an extramedullary man-ifestation of acute myeloid leukemia,and imaging lacks specificity,leading to potential misdiagnosis.Case Presentation:A female patient diagnosed with mixed-phenotype acute leukemia achieved complete remission after chemother-apy and allogeneic hematopoietic stem cell transplantation.However,a relapse occurred in the breast after transplantation.The patient achieved local control through mastectomy and removal of the axillary lymph nodes on the affected side.Unfortunately,during the subse-quent course of chemotherapy,the patient died of a severe pulmonary infection caused by coronavirus disease 2019.Conclusion:Continuous treatment and monitoring of mixed-phenotype acute leukemia patients are essential,especially for those with extramedullary manifestations(such as breast involvement).

关 键 词：BREAST Case report COVID-19 Myeloid sarcoma Mixed-phenotype acute leukemia 

分 类 号：R73[医药卫生—肿瘤]