Extracellular Vesicles in Pathogenic Infection,Transmission,and Immunity  

作　　者：Junyao Xiong Usama Ashraf Jing Ye Shengbo Cao 

机构地区：[1]National Key Laboratory of Agricultural Microbiology,Huazhong Agricultural University,Wuhan 430070,China [2]Frontiers Science Center for Animal Breeding and Sustainable Production,Huazhong Agricultural University,Wuhan 430070,China [3]Hubei Hongshan Laboratory,Wuhan 430070,China [4]The Cooperative Innovation Center for Sustainable Pig Production,Huazhong Agricultural University,Wuhan 430070,China [5]Department of Medicine,Division of Infectious Diseases,Stanford University,Stanford,CA 94305,USA

出　　处：《Engineering》2024年第12期228-240,共13页工程(英文)

基　　金：supported by the National Key Research and Development Program of China(2022YFD1801500 and 2022YFD1800105);the National Natural Science Foundation of China(32030107 and 32372993);the Fundamental Research Funds for the Central Universities(2662023PY005)。

摘　　要：Extracellular vesicles(EVs)are secreted by cells and widely exist in body fluids,serving as an essential vehicle of intercellular communication.In recent years,EVs have gained significant attention owing to their ability to carry nucleic acids,lipids,and proteins of host and pathogen origins.A distinct composition of EVs during pathogenic infection contributes to mediating pathogenic infection,transmission,and immunity to target cells.Therefore,studying the role of EVs in pathogenic infection is crucial for understanding pathogen–host interactions and developing new anti-pathogenic therapies.This review offers an overview of current knowledge of EVs in the context of infection,transmission,and immunity to pathogens.Harnessing EVs'biology during pathogenic infection may lay a foundation for the mitigation of pathogenic infection and associated disease outcomes.

关 键 词：Extracellular vesicles PATHOGEN INFECTION TRANSMISSION IMMUNITY 

分 类 号：R57[医药卫生—消化系统]